The NKT cell TCR repertoire can accommodate structural modifications to the lipid and orientation of the terminal carbohydrate of iGb3
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra02373c
Abstract: Isoglobotrihexosylceramide (iGb3) is a known NKT cell agonist, however the specific interactions required to trigger NKT cell TCR activation in response to this mammalian glycolipid are not fully understood. Here we report the synthesis of… read more here.
Keywords: nkt cell; tcr repertoire; cell tcr; igb3 ... See more keywords
Abstract 4066: High throughput single-cell TCR sequencing method identifies cancer-specific TCR clonotypes
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-4066
Abstract: Cancer cells produce tumor-specific antigens and neoantigens that can be recognized by T cells and induce their clearance. Single cell profiling of T cell receptors (TCRs) and gene expression enables the identification and characterization of… read more here.
Keywords: cancer; single cell; cell; tumor ... See more keywords