Interrogating islets in health and disease with single-cell technologies
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2017.04.012
Abstract: Background Blood glucose levels are tightly controlled by the coordinated actions of hormone-producing endocrine cells that reside in pancreatic islets. Islet cell malfunction underlies diabetes development and progression. Due to the cellular heterogeneity within islets,… read more here.
Keywords: single cell; cell technologies; islet; health disease ... See more keywords
Translational insights from single-cell technologies across the cardiovascular disease continuum.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in cardiovascular medicine"
DOI: 10.1016/j.tcm.2021.02.009
Abstract: Cardiovascular disease is the leading cause of death worldwide. The societal health burden it represents can be reduced by taking preventive measures and developing more effective therapies. Reaching these goals, however, requires a better understanding… read more here.
Keywords: single cell; cell technologies; disease; across cardiovascular ... See more keywords
Energy recovery prospects of fuel cell technologies: sustainability and bioremediation
Sign Up to like & getrecommendations! Published in 2020 at "Australian journal of mechanical engineering"
DOI: 10.1080/14484846.2020.1747152
Abstract: Energy for sustainable development through utilisation of low carbon footprint sources can benefit a nation both economically and prevent detrimental damage to the environment at the same time. Fue... read more here.
Keywords: cell technologies; fuel cell; energy recovery; energy ... See more keywords
The Value of Single-cell Technologies in Solid Organ Transplantation Studies.
Sign Up to like & getrecommendations! Published in 2022 at "Transplantation"
DOI: 10.1097/tp.0000000000004237
Abstract: Single-cell technologies open up new opportunities to explore the behavior of cells at the individual level. For solid organ transplantation, single-cell technologies can provide in-depth insights into the underlying mechanisms of the immunological processes involved… read more here.
Keywords: organ transplantation; cell; cell technologies; single cell ... See more keywords
Distinguishing activated T regulatory cell and T conventional cells by single cell technologies.
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13460
Abstract: BACKGROUND Resting conventional T cells (Tconv) can be distinguished from T regulatory cells (Treg) by the canonical markers FOXP3, CD25 and CD127. However, the expression of these proteins alters after T cell activation leading to… read more here.
Keywords: treg; single cell; tconv; conventional cells ... See more keywords
Achieving a Deeper Understanding of Drug Metabolism and Responses Using Single-Cell Technologies
Sign Up to like & getrecommendations! Published in 2023 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.122.001043
Abstract: Recent advancements in single-cell technologies have enabled detection of RNA, proteins, metabolites, and xenobiotics in individual cells, and the application of these technologies has the potential to transform pharmacological research. Single-cell data has already resulted… read more here.
Keywords: cell; cell technologies; drug metabolism; single cell ... See more keywords
In Synergy: Optimizing CAR T Development and Personalizing Patient Care Using Single-Cell Technologies.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-23-0010
Abstract: Chimeric antigen receptor (CAR) T therapies hold immense promise to revolutionize cancer treatment. Nevertheless, key challenges, primarily in solid tumor settings, continue to hinder the application of this technology. Understanding CAR T-cell mechanism of action,… read more here.
Keywords: cell; development; cell technologies; car ... See more keywords
How Single-Cell Technologies Have Provided New Insights Into Atherosclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.121.315849
Abstract: The development of innovative single-cell technologies has allowed the high-dimensional transcriptomic and proteomic profiling of individual blood and tissue cells. Recent single-cell studies revealed a new cellular heterogeneity of atherosclerotic plaque tissue and allowed a… read more here.
Keywords: provided new; cell technologies; atherosclerosis; cell ... See more keywords
Breaking the Immune Complexity of the Tumor Microenvironment Using Single-Cell Technologies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.867880
Abstract: Tumors are not a simple aggregate of transformed cells but rather a complicated ecosystem containing various components, including infiltrating immune cells, tumor-related stromal cells, endothelial cells, soluble factors, and extracellular matrix proteins. Profiling the immune… read more here.
Keywords: cell; tumor microenvironment; cell technologies; single cell ... See more keywords
Single-Cell Technologies for the Study of Antibody-Secreting Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.821729
Abstract: Antibody-secreting cells (ASC), plasmablasts and plasma cells, are terminally differentiated B cells responsible for large-scale production and secretion of antibodies. ASC are derived from activated B cells, which may differentiate extrafollicularly or form germinal center… read more here.
Keywords: cell; secreting cells; cell technologies; single cell ... See more keywords
Single-Cell Technologies to Decipher the Immune Microenvironment in Myeloid Neoplasms: Perspectives and Opportunities
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.796477
Abstract: Myeloid neoplasms (MN) are heterogeneous clonal disorders arising from the expansion of hematopoietic stem and progenitor cells. In parallel with genetic and epigenetic dynamics, the immune system plays a critical role in modulating tumorigenesis, evolution… read more here.
Keywords: cell; decipher immune; cell technologies; myeloid neoplasms ... See more keywords