Materials for Cell Surface Engineering.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202210059
Abstract: Cell therapies are emerging as a promising new therapeutic modality in medicine, generating effective treatments of previously incurable diseases. Clinical success of cell therapies has energized the field of cellular engineering, spurring further exploration of… read more here.
Keywords: cell; cell surface; surface engineering; engineering ... See more keywords
Better by design: What to expect from novel CAR-engineered cell therapies?
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology advances"
DOI: 10.1016/j.biotechadv.2022.107917
Abstract: Chimeric antigen receptor (CAR) technology, and CAR-T cells in particular, have emerged as a new and powerful tool in cancer immunotherapy since demonstrating efficacy against several hematological malignancies. However, despite encouraging clinical results of CAR-T… read more here.
Keywords: cell therapies; car engineered; novel car; engineered cell ... See more keywords
Screening for the Next-Generation T Cell Therapies.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer cell"
DOI: 10.1016/j.ccell.2020.04.009
Abstract: In a recently published Cell paper, Roth et al. report a CRISPR-based platform for developing T cell therapies that strategically combine a tumor-specific TCR with novel protein factors that potentiate antitumor function. read more here.
Keywords: cell therapies; cell; generation cell; screening next ... See more keywords
Discriminatory Power of Combinatorial Antigen Recognition in Cancer T Cell Therapies.
Sign Up to like & getrecommendations! Published in 2020 at "Cell systems"
DOI: 10.1016/j.cels.2020.08.002
Abstract: Precise discrimination of tumor from normal tissues remains a major roadblock for therapeutic efficacy of chimeric antigen receptor (CAR) T cells. Here, we perform a comprehensive in silico screen to identify multi-antigen signatures that improve tumor… read more here.
Keywords: cell therapies; antigen; car; discrimination ... See more keywords
NextGen cell-based immunotherapies in cancer and other immune disorders.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2019.03.007
Abstract: T lymphocyte and other cell therapies have the potential to transform how we treat cancers and other diseases that have few therapeutic options. Here, we review the current progress in engineered T cell therapies and… read more here.
Keywords: cell therapies; nextgen cell; cell based; biology ... See more keywords
Approved CAR T cell therapies: ice bucket challenges on glaring safety risks and long-term impacts.
Sign Up to like & getrecommendations! Published in 2018 at "Drug discovery today"
DOI: 10.1016/j.drudis.2018.02.012
Abstract: Two autologous chimeric antigen receptor (CAR) T cell therapies (Kymriah™ and Yescarta™) were recently approved by the FDA. Kymriah™ is for the treatment of pediatric patients and young adults with refractory or relapse (R/R) B… read more here.
Keywords: car cell; cell therapies; term; glaring safety ... See more keywords
Taking T-Cell Oncotherapy Off-the-Shelf.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in immunology"
DOI: 10.1016/j.it.2021.01.004
Abstract: Banked allogeneic or 'off-the-shelf' (OTS) T cells from healthy human donors are being developed to address the limitations of autologous cell therapies. Potential challenges of OTS T cell therapies are associated with their allogeneic origin… read more here.
Keywords: cell therapies; cell oncotherapy; ots cells; taking cell ... See more keywords
Toward precision manufacturing of immunogene T-cell therapies.
Sign Up to like & getrecommendations! Published in 2018 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2017.12.007
Abstract: Cancer can be effectively targeted using a patient's own T cells equipped with synthetic receptors, including chimeric antigen receptors (CARs) that redirect and reprogram these lymphocytes to mediate tumor rejection. Over the past two decades,… read more here.
Keywords: cell therapies; toward precision; precision manufacturing; immunogene cell ... See more keywords
Advancing the robust manufacture of t-cell therapies through the application of stirred tank bioreactors
Sign Up to like & getrecommendations! Published in 2019 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2019.03.365
Abstract: Background & Aim With over 90 active trials in the United States with many more in pre-clinical phases T-Cell immunotherapies represent a large share of the expansion we are observing in the regenerative medicine industry.… read more here.
Keywords: cell therapies; stirred tank; tank bioreactors; cell ... See more keywords
High throughput performance-based selection and expansion of clonal progenitor populations resident in human articular cartilage to characterize sub-populations for effective cartilage stem cell therapies
Sign Up to like & getrecommendations! Published in 2019 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2019.03.525
Abstract: Background & Aim Enormous heterogeneity in autogenous tissue sources of mesenchymal stromal cells (MSCs) with respect to the quantity and quality of the stem and progenitor cells that serve as the starting materials for cellular… read more here.
Keywords: cell therapies; stem cell; progenitor; cell ... See more keywords
A Sensitive and Controlled Data-Independent Acquisition Method for Proteomic Analysis of Cell Therapies.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.1c00887
Abstract: Mass spectrometry (MS)-based proteomic measurements are uniquely poised to impact the development of cell and gene therapies. With the adoption of rigorous instrumental performance qualifications (PQs), large-scale proteomics can move from a research to a… read more here.
Keywords: cell therapies; independent acquisition; acquisition; method ... See more keywords