Insights Into Cardiovascular Risks of Chimeric Antigen Receptor T-Cell Therapy-From Peril to Promise.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2024.37157
Abstract: The development of autologous chimeric antigen receptor (CAR) T-cell therapy is a momentous breakthrough as the first personalized, genetically engineered living therapy. Reported initially at the bench in 1987, 1 over the span of the… read more here.
Keywords: receptor; cell therapy; antigen; car ... See more keywords
Barriers to Chimeric Antigen Receptor T-Cell Therapy.
Sign Up to like & getrecommendations! Published in 2025 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2025.1127
Abstract: This cohort study examines barriers to access of CAR T-cell therapy among patients with hematologic cancer referred for this treatment. read more here.
Keywords: cell therapy; chimeric antigen; antigen receptor; barriers chimeric ... See more keywords
In Situ Reprogramming of Immune Cells Using Synthetic Nanomaterials
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Materials"
DOI: 10.1002/adma.202310168
Abstract: In the past decade, adoptive cell therapy with chimeric antigen receptor‐T (CAR‐T) cells has revolutionized cancer treatment. However, the complexity and high costs involved in manufacturing current adoptive cell therapy greatly inhibit its widespread availability… read more here.
Keywords: cell therapy; immune cells; reprogramming immune; synthetic nanomaterials ... See more keywords
Grooved Microneedle Patch Augments Adoptive T Cell Therapy Against Solid Tumors via Diverting Regulatory T Cells
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Materials"
DOI: 10.1002/adma.202401667
Abstract: The efficacy of adoptive T cell therapy (ACT) for the treatment of solid tumors remains challenging. In addition to the poor infiltration of effector T (Teff) cells limited by the physical barrier surrounding the solid… read more here.
Keywords: cell therapy; grooved microneedle; solid tumors; cell ... See more keywords
Efficient Artificial T Cell Therapy for Bacterial‐Colonized Tumors
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Materials"
DOI: 10.1002/adma.202503087
Abstract: Tumor‐colonizing bacteria can impede the efficacy of cancer treatments and elevate the risk of metastatic spread. While cytotoxic T lymphocytes (CTLs) are essential for destroying tumor cells, they lack the ability to eliminate bacteria. Here,… read more here.
Keywords: cell therapy; artificial cell; tumor; cell ... See more keywords
Immuno-Packed T-Cell-Fusogenic Liposome Empowers Adoptive T Cell Therapy for Solid Tumor Treatment.
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DOI: 10.1002/adma.202510842
Abstract: Adoptive T cell therapy has achieved remarkable success in certain blood cancers, but its efficacy against solid tumors remains limited by multiple immunological challenges including inadequate tumor infiltration, tumor cell's immune tolerance, and immunosuppressive tumor microenvironment… read more here.
Keywords: cell therapy; cell; tumor; therapy solid ... See more keywords
A Novel Engineering Cell Therapy Platform Mimicking the Immune Thrombocytopenia‐Derived Platelets to Inhibit Cytokine Storm in Hemophagocytic Lymphohistiocytosis (Adv. Sci. 45/2024)
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202470277
Abstract: Living Therapeutics Platform The image illustration vividly depicts the story of the Storm's end Pearl from Journey to the West. The Yellow Wind Demon and the fierce storm he unleashes symbolize macrophages and cytokine storms.… read more here.
Keywords: engineering cell; cell therapy; storm; novel engineering ... See more keywords
Advanced Stem Cell Therapy: 3D-Bioprinted Brain-Like Transplants for Alzheimer's Disease-Like Dementia.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202510062
Abstract: Alzheimer's disease (AD) is a neurodegenerative disorder that lacks effective treatments and urgently requires innovative therapeutic strategies. Although stem cell therapy has demonstrated efficacy in preclinical and clinical studies, it faces challenges such as low… read more here.
Keywords: stem cell; alzheimer disease; cell; cell therapy ... See more keywords
Prolonged hematologic toxicity following treatment with chimeric antigen receptor T cells in patients with hematologic malignancies
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26113
Abstract: Chimeric antigen receptor T‐cell therapy (CAR T) is a novel intervention for relapsed/refractory diffuse large B‐cell lymphoma (R/R DLBCL) and other hematologic malignancies. However, it is associated with prolonged hematologic toxicity (PHT) that is unpredictable… read more here.
Keywords: hematologic toxicity; cell therapy; prolonged hematologic; toxicity ... See more keywords
Bioprocess considerations for T‐cell therapy: Investigating the impact of agitation, dissolved oxygen, and pH on T‐cell expansion and differentiation
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27468
Abstract: Adoptive T‐cell therapy (ACT) has emerged as a promising new way to treat systemic cancers such as acute lymphoblastic leukemia. However, the robustness and reproducibility of the manufacturing process remains a challenge. Here, a single‐use… read more here.
Keywords: cell therapy; bioprocess considerations; differentiation; dissolved oxygen ... See more keywords
Chimeric antigen receptor T (CAR‐T) cells: Novel cell therapy for hematological malignancies
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5551
Abstract: Over the last decade, the emergence of several novel therapeutic approaches has changed the therapeutic perspective of human malignancies. Adoptive immunotherapy through chimeric antigen receptor T cell (CAR‐T), which includes the engineering of T cells… read more here.
Keywords: cell; antigen receptor; chimeric antigen; cell therapy ... See more keywords