Prolonged hematologic toxicity following treatment with chimeric antigen receptor T cells in patients with hematologic malignancies
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26113
Abstract: Chimeric antigen receptor T‐cell therapy (CAR T) is a novel intervention for relapsed/refractory diffuse large B‐cell lymphoma (R/R DLBCL) and other hematologic malignancies. However, it is associated with prolonged hematologic toxicity (PHT) that is unpredictable… read more here.
Keywords: hematologic toxicity; cell therapy; prolonged hematologic; toxicity ... See more keywords
Bioprocess considerations for T‐cell therapy: Investigating the impact of agitation, dissolved oxygen, and pH on T‐cell expansion and differentiation
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27468
Abstract: Adoptive T‐cell therapy (ACT) has emerged as a promising new way to treat systemic cancers such as acute lymphoblastic leukemia. However, the robustness and reproducibility of the manufacturing process remains a challenge. Here, a single‐use… read more here.
Keywords: cell therapy; bioprocess considerations; differentiation; dissolved oxygen ... See more keywords
Chimeric antigen receptor T (CAR‐T) cells: Novel cell therapy for hematological malignancies
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5551
Abstract: Over the last decade, the emergence of several novel therapeutic approaches has changed the therapeutic perspective of human malignancies. Adoptive immunotherapy through chimeric antigen receptor T cell (CAR‐T), which includes the engineering of T cells… read more here.
Keywords: cell; antigen receptor; chimeric antigen; cell therapy ... See more keywords
Treg cell therapy: How cell heterogeneity can make the difference
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.201948131
Abstract: CD4+CD25highCD127low/−FOXP3+ T regulatory cells are responsible for maintaining immune tolerance and controlling excessive immune responses. Treg cell use in pre‐clinical animal models showed the huge therapeutic potential of these cells in immune‐mediated diseases and laid… read more here.
Keywords: cell therapy; treg cells; cell; treg cell ... See more keywords
Antigen receptor‐engineered Tregs inhibit CNS autoimmunity in cell therapy using nonredundant immune mechanisms in mice
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202249845
Abstract: CD4+FOXP3+ Tregs are currently explored to develop cell therapies against immune‐mediated disorders, with an increasing focus on antigen receptor‐engineered Tregs. Deciphering their mode of action is necessary to identify the strengths and limits of this… read more here.
Keywords: cell therapy; receptor engineered; engineered tregs; antigen receptor ... See more keywords
Overcoming resistance to anti‐CD19 CAR T‐cell therapy in B‐cell malignancies
Sign Up to like & getrecommendations! Published in 2022 at "Hematological Oncology"
DOI: 10.1002/hon.3036
Abstract: Anti‐CD19 chimeric antigen receptor (CAR) T‐cell therapy has rapidly changed current treatment pattern, providing a better option for individuals with primary refractory or relapsed B‐cell non‐Hodgkin lymphoma (r/r B‐NHL) and B‐cell acute lymphoblastic leukemia (r/r… read more here.
Keywords: cell; cd19; cell therapy; car ... See more keywords
Combination of PD‐1/PD‐L1 checkpoint inhibition and dendritic cell therapy in mice models and in patients with mesothelioma
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34293
Abstract: Immunotherapy with anti‐PD1/PD‐L1 is effective in only a subgroup of patients with malignant pleural mesothelioma (MPM). We investigated the efficacy of a combination of anti‐PD1/PD‐L1 and dendritic cell (DC) therapy to optimally induce effective anti‐tumor… read more here.
Keywords: cell; combination; dendritic cell; therapy ... See more keywords
Umbilical cord blood stem cell therapy in premature brain injury: Opportunities and challenges
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24548
Abstract: Preterm birth and associated brain injury are the primary cause of cerebral palsy and developmental disabilities and are among the most serious global health issues that modern society faces. Current therapy for infants suffering from… read more here.
Keywords: stem cell; brain injury; brain; cell therapy ... See more keywords
CAR T‐cell therapy for pancreatic cancer
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.24627
Abstract: Chimeric antigen receptor (CAR) T‐cell therapy utilizes genetic engineering to redirect a patient's own T cells to target cancer cells. The remarkable results in hematological malignancies prompted investigating this approach in solid tumors such as… read more here.
Keywords: cancer; cell therapy; car cell; pancreatic cancer ... See more keywords
Human Fetal Cell Therapy in Huntington's Disease: A Randomized, Multicenter, Phase II Trial
Sign Up to like & getrecommendations! Published in 2020 at "Movement Disorders"
DOI: 10.1002/mds.28201
Abstract: Huntington's disease is a rare, severe, inherited neurodegenerative disease in which we assessed the safety and efficacy of grafting human fetal ganglionic eminence intrastriatally. read more here.
Keywords: cell therapy; huntington disease; human fetal; fetal cell ... See more keywords
Toward a Personalized Approach to Parkinson's Cell Therapy
Sign Up to like & getrecommendations! Published in 2020 at "Movement Disorders"
DOI: 10.1002/mds.28328
Abstract: We appreciate the opportunity to respond to the Viewpoint by Drs. Jankovic, Okun, and Kordower referencing our recent publication in the New England Journal of Medicine on the use of autologous skin cells, reprogrammed via… read more here.
Keywords: medicine; parkinson; cell therapy; approach ... See more keywords