Suppression of Autoimmune Rheumatoid Arthritis with Hybrid Nanoparticles That Induce B and T Cell Tolerance to Self-Antigen.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.2c05643
Abstract: Autoimmune diseases affect over 4% of the world's population. Treatments are generally palliative or use broad spectrum immunosuppressants to reduce symptoms and disease progression. In some diseases, antibodies generated to a single autoantigen are the… read more here.
Keywords: cell; rheumatoid arthritis; self antigen; tolerance ... See more keywords
Many Achilles’ heels of B and T cell tolerance
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DOI: 10.1111/imr.13076
Abstract: Generation of enormous antigen receptor repertoire diversity through random VDJ recombination is the cornerstone of the adaptive immune system, but it comes at the cost of generating large numbers of selfreactive lymphocytes with potential for… read more here.
Keywords: heels cell; achilles heels; tolerance; many achilles ... See more keywords
Spatiotemporal regulation of peripheral T cell tolerance
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DOI: 10.1126/science.adg6425
Abstract: The incomplete removal of T cells that are reactive against self-proteins during their differentiation in the thymus requires mechanisms of tolerance that prevent their effector function within the periphery. A further challenge is imposed by… read more here.
Keywords: cell; peripheral cell; regulation peripheral; tolerance ... See more keywords
SHP-1 localization to the activating immune synapse promotes NK cell tolerance in MHC class I deficiency
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DOI: 10.1126/scisignal.abq0752
Abstract: Natural killer (NK) cells recognize virally infected cells and tumors. NK cell function depends on balanced signaling from activating receptors, recognizing products from tumors or viruses, and inhibitory receptors (such as KIR/Ly49), which recognize major… read more here.
Keywords: cell; shp; education; synapse ... See more keywords
Breaking β Cell Tolerance After 100 Years of Life: Intratumoral Immunotherapy–Induced Diabetes Mellitus
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DOI: 10.1210/jendso/bvaa114
Abstract: Abstract Cancer immunotherapies are changing the landscape of cancer care. Intratumoral talimogene iaherparepvec (T-VEC), an oncolytic viral vaccine, has been approved for treatment of unresectable melanoma with minimal toxicity. We describe the first case of… read more here.
Keywords: cell tolerance; breaking cell; immunotherapy; autoimmune diabetes ... See more keywords
Strategies to induce natural killer cell tolerance in xenotransplantation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.941880
Abstract: Eliminating major xenoantigens in pig cells has drastically reduced human antibody-mediated hyperacute xenograft rejection (HXR). Despite these advancements, acute xenograft rejection (AXR) remains one of the major obstacles to clinical xenotransplantation, mediated by innate immune… read more here.
Keywords: cell; natural killer; xenotransplantation; cell tolerance ... See more keywords