Cell trafficking and regulation of osteoblastogenesis by extracellular vesicle associated bone morphogenetic protein 2.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of extracellular vesicles"
DOI: 10.1002/jev2.12155
Abstract: Extracellular vesicles (EVs) are characterized by complex cargo composition and carry a wide array of signalling cargo, including growth factors (GFs). Beyond surface-associated GFs, it is unclear if EV intralumenal growth factors are biologically active.… read more here.
Keywords: cell trafficking; bmp2; evs; osteoblastogenesis ... See more keywords
R4 RGS proteins as fine tuners of immature and mature hematopoietic cell trafficking
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.1mr0422-475r
Abstract: G‐protein‐coupled receptors (GPCRs) are the largest and most diverse group of membrane receptors. They are involved in almost every physiologic process and consequently have a pivotal role in an extensive number of pathologies, including genetic,… read more here.
Keywords: cell; proteins fine; tuners immature; fine tuners ... See more keywords
T helper cell trafficking in autoimmune kidney diseases.
Sign Up to like & getrecommendations! Published in 2021 at "Cell and tissue research"
DOI: 10.1007/s00441-020-03403-6
Abstract: CD4+ T cells are key drivers of autoimmune diseases, including crescentic GN. Many effector mechanisms employed by T cells to mediate renal damage and repair, such as local cytokine production, depend on their presence at… read more here.
Keywords: cell trafficking; trafficking autoimmune; cell; autoimmune kidney ... See more keywords
Controlling in and out – the future of interfering with immune cell trafficking in inflammatory bowel disease
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Clinical Immunology"
DOI: 10.1080/1744666x.2023.2152794
Abstract: ABSTRACT Introduction Immune cell trafficking is a key requirement in the pathogenesis of inflammatory bowel diseases. Consistently, therapeutic strategies to target immune cell trafficking have been established and continue to be developed for the treatment… read more here.
Keywords: immune cell; cell trafficking; inflammatory bowel;
Novel Insights into the Mechanisms of Gut Homing and Antiadhesion Therapies in Inflammatory Bowel Diseases.
Sign Up to like & getrecommendations! Published in 2017 at "Inflammatory bowel diseases"
DOI: 10.1097/mib.0000000000001067
Abstract: Therapeutic compounds interfering with T cell trafficking are a new column of inflammatory bowel disease (IBD) treatment. Currently, the anti-α4β7 integrin antibody vedolizumab is successfully used in the clinic and further drugs are likely to… read more here.
Keywords: cell trafficking; bowel; inflammatory bowel; bowel diseases ... See more keywords
Reassessment of the blood-brain barrier: a potential target for viral entry into the immune-privileged brain.
Sign Up to like & getrecommendations! Published in 2022 at "Germs"
DOI: 10.18683/germs.2022.1310
Abstract: [...]a "leaky" BBB may facilitate direct viral access to cortical neurons involved in the processing and integration of cognitive behaviors. Viruses may elicit CNS dysfunction via direct penetration of the BBB or they may enter… read more here.
Keywords: immune cell; brain; cell trafficking; virus ... See more keywords
CD11c+ Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.00099
Abstract: Type 1 diabetes (T1D) is a T cell mediated autoimmune disease that affects more than 19 million people with incidence increasing rapidly worldwide. For T cells to effectively drive T1D, they must first traffic to… read more here.
Keywords: cell trafficking; infiltrated islets; trafficking infiltrated; type diabetes ... See more keywords
Alpha4 beta7 integrin controls Th17 cell trafficking in the spinal cord leptomeninges during experimental autoimmune encephalomyelitis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1071553
Abstract: Th1 and Th17 cell migration into the central nervous system (CNS) is a fundamental process in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS). Particularly, leptomeningeal vessels of the… read more here.
Keywords: cell; th1; integrin; th17 ... See more keywords
P66Shc: A Pleiotropic Regulator of B Cell Trafficking and a Gatekeeper in Chronic Lymphocytic Leukemia
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12041006
Abstract: Neoplastic B cells from chronic lymphocytic leukemia patients (CLL) have a profound deficiency in the expression of p66Shc, an adaptor protein with pro-apoptotic and pro-oxidant activities. This defect results in leukemic B cell resistance to… read more here.
Keywords: cell trafficking; lymphocytic leukemia; p66shc; chronic lymphocytic ... See more keywords