Alignment of single-cell trajectories to compare cellular expression dynamics
Sign Up to like & getrecommendations! Published in 2018 at "Nature Methods"
DOI: 10.1038/nmeth.4628
Abstract: Single-cell RNA sequencing and high-dimensional cytometry can be used to generate detailed trajectories of dynamic biological processes such as differentiation or development. Here we present cellAlign, a quantitative framework for comparing expression dynamics within and… read more here.
Keywords: single cell; alignment single; expression dynamics; cell trajectories ... See more keywords
Reconstruction of complex single-cell trajectories using CellRouter
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03214-y
Abstract: A better understanding of the cell-fate transitions that occur in complex cellular ecosystems in normal development and disease could inform cell engineering efforts and lead to improved therapies. However, a major challenge is to simultaneously… read more here.
Keywords: single cell; trajectories using; cellrouter; reconstruction complex ... See more keywords
Single-cell trajectories reconstruction, exploration and mapping of omics data with STREAM
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09670-4
Abstract: Single-cell transcriptomic assays have enabled the de novo reconstruction of lineage differentiation trajectories, along with the characterization of cellular heterogeneity and state transitions. Several methods have been developed for reconstructing developmental trajectories from single-cell transcriptomic… read more here.
Keywords: single cell; trajectories single; stream; cell transcriptomic ... See more keywords