Single Cell Transcriptomes Derived from Human Cervical and Uterine Tissue during Pregnancy
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Biosystems"
DOI: 10.1002/adbi.201800336
Abstract: This work presents the workflow for generating single cell transcriptomes derived from primary human uterine and cervical tissue obtained during planned cesarean hysterectomies. In total, a catalogue of 310 single cell transcriptomes are obtained, cell… read more here.
Keywords: single cell; tissue; cell transcriptomes; transcriptomes derived ... See more keywords
Synthetic Analyses of Single-Cell Transcriptomes from Multiple Brain Organoids and Fetal Brain
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.01.038
Abstract: SUMMARY Human brain organoid systems offer unprecedented opportunities to investigate both neurodevelopmental and neurological disease. Single-cell-based transcriptomics or epigenomics have dissected the cellular and molecular heterogeneity in the brain organoids, revealing a complex organization. Similar… read more here.
Keywords: single cell; fetal brain; cell transcriptomes; brain organoids ... See more keywords
Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors
Sign Up to like & getrecommendations! Published in 2017 at "Nature Genetics"
DOI: 10.1038/ng.3818
Abstract: Intratumoral heterogeneity is a major obstacle to cancer treatment and a significant confounding factor in bulk-tumor profiling. We performed an unbiased analysis of transcriptional heterogeneity in colorectal tumors and their microenvironments using single-cell RNA–seq from… read more here.
Keywords: single cell; heterogeneity; analysis; cell transcriptomes ... See more keywords
MAT2: Manifold alignment of single-cell transcriptomes with cell triplets.
Sign Up to like & getrecommendations! Published in 2021 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btab250
Abstract: MOTIVATION Aligning single-cell transcriptomes is important for the joint analysis of multiple single-cell RNA sequencing datasets, which in turn is vital to establishing a holistic cellular landscape of certain biological processes. Although numbers of approaches… read more here.
Keywords: single cell; cell transcriptomes; cell triplets; cell ... See more keywords
Single-cell transcriptomes in the heart: when every epigenome counts.
Sign Up to like & getrecommendations! Published in 2022 at "Cardiovascular research"
DOI: 10.1093/cvr/cvac040
Abstract: The response of an organ to stimuli emerges from the actions of individual cells. Recent cardiac single cell RNA-sequencing studies of development, injury and reprogramming have uncovered heterogeneous populations even among previously well-defined cell types,… read more here.
Keywords: cell; heart every; single cell; cell transcriptomes ... See more keywords
Detecting critical transition signals from single-cell transcriptomes to infer lineage-determining transcription factors
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac452
Abstract: Abstract Analyzing single-cell transcriptomes promises to decipher the plasticity, heterogeneity, and rapid switches in developmental cellular state transitions. Such analyses require the identification of gene markers for semi-stable transition states. However, there are nontrivial challenges… read more here.
Keywords: lineage determining; critical transition; determining transcription; single cell ... See more keywords
Single-cell transcriptomes and runx2b−/− mutants reveal the genetic signatures of intermuscular bone formation in zebrafish
Sign Up to like & getrecommendations! Published in 2022 at "National Science Review"
DOI: 10.1093/nsr/nwac152
Abstract: Abstract Intermuscular bones (IBs) are mineralized spicules, present in the myosepta of many, but not all, teleost species. IBs are often small and sharp, and they consequently limit how the fish can be processed; the… read more here.
Keywords: cell; bone; single cell; cell transcriptomes ... See more keywords
Single-cell transcriptomes and T cell receptors of vaccine-expanded apolipoprotein B-specific T cells
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.1076808
Abstract: Atherosclerotic cardiovascular diseases are the major cause of death worldwide. CD4 T cells responding to Apolipoprotein B (ApoB), the core protein of most lipoproteins, have been identified as critical disease modulators. In healthy individuals, ApoB-reactive… read more here.
Keywords: cell; apob; single cell; cell transcriptomes ... See more keywords
Single cell RNA sequencing analysis of mouse cochlear supporting cell transcriptomes with activated ERBB2 receptor indicates a cell-specific response that promotes CD44 activation
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.1096872
Abstract: Hearing loss caused by the death of cochlear hair cells (HCs) might be restored through regeneration from supporting cells (SCs) via dedifferentiation and proliferation, as observed in birds. In a previous report, ERBB2 activation in… read more here.
Keywords: cell; mouse cochlear; activated erbb2; single cell ... See more keywords
The emerging double-edged sword role of Sirtuins in the gastric inflammation-carcinoma sequence revealed by bulk and single-cell transcriptomes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1004726
Abstract: Histone modification and the inflammation-carcinoma sequence (ICS) have been acknowledgedly implicated in gastric carcinogenesis. However, the extremum expression of some histone modification genes (HMGs) in intestinal metaplasia (IM) rather than GC obscures the roles of… read more here.
Keywords: inflammation carcinoma; cell; single cell; cell transcriptomes ... See more keywords