Single‐Cell Transcriptomic Analysis Identifies a Novel OLR1 + SLC7A7 + Liver‐Enriched Metastatic Subset With Immunometabolic Rewiring in Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Medicine"
DOI: 10.1002/cam4.71345
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is an exceptionally lethal malignancy, with high percents of patients presenting with liver metastases (LM). However, the mechanisms driving liver metastases remain critical bottlenecks requiring urgent exploration. read more here.
Keywords: cancer; single cell; cell transcriptomic; analysis identifies ... See more keywords
Single-Cell Transcriptomic Analysis.
Sign Up to like & getrecommendations! Published in 2020 at "Comprehensive Physiology"
DOI: 10.1002/cphy.c190037
Abstract: Single-cell sequencing measures the sequence information from individual cells using optimized single-cell isolation protocols and next-generation sequencing technologies. Recent advancement in single-cell sequencing has transformed biomedical research, providing insights into diverse biological processes such as… read more here.
Keywords: single cell; cell transcriptomic; transcriptomic analysis; physiology ... See more keywords
Single-Cell Transcriptomic Analysis in the Regenerating Cnidarian Nematostella vectensis.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-2172-1_30
Abstract: Cnidarians have historically served as excellent laboratory models for regenerative development given their capacity to regrow large portions of the adult organism. This capacity is notably absent or poorly developed in the powerful genetic laboratory… read more here.
Keywords: cell transcriptomic; cell; single cell; nematostella vectensis ... See more keywords
Cancer biology deciphered by single-cell transcriptomic sequencing.
Sign Up to like & getrecommendations! Published in 2021 at "Protein & cell"
DOI: 10.1007/s13238-021-00868-1
Abstract: Tumors are complex ecosystems in which heterogeneous cancer cells interact with their microenvironment composed of diverse immune, endothelial, and stromal cells. Cancer biology had been studied using bulk genomic and gene expression profiling, which however… read more here.
Keywords: single cell; cell transcriptomic; biology; cancer biology ... See more keywords
Single-cell trajectories reconstruction, exploration and mapping of omics data with STREAM
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09670-4
Abstract: Single-cell transcriptomic assays have enabled the de novo reconstruction of lineage differentiation trajectories, along with the characterization of cellular heterogeneity and state transitions. Several methods have been developed for reconstructing developmental trajectories from single-cell transcriptomic… read more here.
Keywords: single cell; trajectories single; stream; cell transcriptomic ... See more keywords
The single-cell transcriptomic atlas and RORA-mediated 3D epigenomic remodeling in driving corneal epithelial differentiation
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-023-44471-w
Abstract: Proper differentiation of corneal epithelial cells (CECs) from limbal stem/progenitor cells (LSCs) is required for maintenance of ocular homeostasis and clear vision. Here, using a single-cell transcriptomic atlas, we delineate the comprehensive and refined molecular… read more here.
Keywords: differentiation; single cell; cell transcriptomic; corneal epithelial ... See more keywords
A brief review of single-cell transcriptomic technologies.
Sign Up to like & getrecommendations! Published in 2018 at "Briefings in functional genomics"
DOI: 10.1093/bfgp/elx019
Abstract: In recent years, there has been an effort to develop new technologies for measuring gene expression and sequence information from thousands of individual cells. Large data sets that were obtained using these 'single cell' technologies… read more here.
Keywords: single cell; cell; cell transcriptomic; review single ... See more keywords
A hybrid deep learning framework for gene regulatory network inference from single-cell transcriptomic data
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbab568
Abstract: Inferring gene regulatory networks (GRNs) based on gene expression profiles is able to provide an insight into a number of cellular phenotypes from the genomic level and reveal the essential laws underlying various life phenomena.… read more here.
Keywords: cell; network; cell transcriptomic; single cell ... See more keywords
BISC: accurate inference of transcriptional bursting kinetics from single-cell transcriptomic data
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac464
Abstract: Gene expression in mammalian cells is inherently stochastic and mRNAs are synthesized in discrete bursts. Single-cell transcriptomics provides an unprecedented opportunity to explore the transcriptome-wide kinetics of transcriptional bursting. However, current analysis methods provide limited… read more here.
Keywords: bursting; cell; bisc; cell transcriptomic ... See more keywords
Single-cell transcriptomic analyses reveal cellular and molecular patterns of rose petal responses to gray mold infection
Sign Up to like & getrecommendations! Published in 2025 at "Horticulture Research"
DOI: 10.1093/hr/uhaf152
Abstract: Abstract Roses (Rosa hybrida) are the most popular cut flower plants worldwide, accounting for over a third of the global cut flower industry. Gray mold, caused by Botrytis cinerea, is often referred to as the… read more here.
Keywords: single cell; cell transcriptomic; gray mold; infection ... See more keywords
Single-cell transcriptomic studies unveil potential nodes of the notochord gene regulatory network.
Sign Up to like & getrecommendations! Published in 2024 at "Integrative and comparative biology"
DOI: 10.1093/icb/icae084
Abstract: Transcription factors (TFs) are DNA-binding proteins able to modulate the timing, location and levels of gene expression by binding to regulatory DNA regions. Therefore, the repertoire of notochord TFs present in the genome of a… read more here.
Keywords: single cell; cell transcriptomic; studies unveil; gene ... See more keywords