Protein structural disorder of the envelope V3 loop contributes to the switch in human immunodeficiency virus type 1 cell tropism
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DOI: 10.1371/journal.pone.0185790
Abstract: Human immunodeficiency virus type 1 (HIV-1) envelope gp120 is partly an intrinsically disordered (unstructured/disordered) protein as it contains regions that do not fold into well-defined protein structures. These disordered regions play important roles in HIV’s… read more here.
Keywords: cell tropism; structural disorder; disorder; loop ... See more keywords
Endothelial cell tropism is a determinant of H5N1 pathogenesis in mammalian species
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DOI: 10.1371/journal.ppat.1006270
Abstract: The cellular and molecular mechanisms underpinning the unusually high virulence of highly pathogenic avian influenza H5N1 viruses in mammalian species remains unknown. Here, we investigated if the cell tropism of H5N1 virus is a determinant… read more here.
Keywords: cell tropism; mammalian species; h5n1; endothelial cells ... See more keywords
Mechanistic Interplay between HIV-1 Reverse Transcriptase Enzyme Kinetics and Host SAMHD1 Protein: Viral Myeloid-Cell Tropism and Genomic Mutagenesis
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DOI: 10.3390/v14081622
Abstract: Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) has been the primary interest among studies on antiviral discovery, viral replication kinetics, drug resistance, and viral evolution. Following infection and entry into target cells, the… read more here.
Keywords: cell tropism; hiv reverse; mutagenesis; hiv ... See more keywords