Promoter methylation of DNA homologous recombination genes is predictive of the responsiveness to PARP inhibitor treatment in testicular germ cell tumors
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12909
Abstract: Testicular germ cell tumors (TGCTs) are the most common cancers in men aged 15–39 years and are divided into two major groups, seminomas and nonseminomas. Novel treatment options are required for these patients, to limit… read more here.
Keywords: methylation; testicular germ; promoter methylation; germ cell ... See more keywords
Profiling the 3D interaction between germ cell tumors and microenvironmental cells at the transcriptome and secretome level
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13282
Abstract: The tumor microenvironment (TM), consisting of the extracellular matrix (ECM), fibroblasts, endothelial cells, and immune cells, might affect tumor invasiveness and the outcome of standard chemotherapy. This study investigated the cross talk between germ cell… read more here.
Keywords: germ cell; secretome level; cell; cell tumors ... See more keywords
Extragonadal germ cell tumors: Not just a matter of location. A review about clinical, molecular and pathological features
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2195
Abstract: Extragonadal germ cell tumors (EGGCTs) are uncommon neoplasms, which arise in anatomical locations other than gonads. The pathogenesis of these neoplasms is still poorly understood and it is a matter of debate if they really… read more here.
Keywords: cell tumors; extragonadal germ; germ cell; diagnosis ... See more keywords
α‐Fetoprotein as a predictor of outcome for children with germ cell tumors: A report from the Malignant Germ Cell International Consortium
Sign Up to like & getrecommendations! Published in 2019 at "Cancer"
DOI: 10.1002/cncr.32363
Abstract: There are several studies describing the correlation between unsatisfactory tumor marker decline and a poor prognosis for adult patients treated for germ cell tumors. In pediatric patients, the data are limited. Therefore, this study retrospectively… read more here.
Keywords: fetoprotein predictor; cell; predictor outcome; germ cell ... See more keywords
Cytologic features of gynecologic germ cell tumors and carcinomas exhibiting germ cell tumor differentiation
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Cytopathology"
DOI: 10.1002/cncy.22673
Abstract: In this study, the authors sought to describe the cytologic features of primary gynecologic germ cell tumors and carcinomas exhibiting germ cell differentiation because little information currently exists. read more here.
Keywords: germ cell; germ; cytologic features; gynecologic germ ... See more keywords
Ultrasound‐guided fine needle aspiration cytology in the diagnosis of hepatic and pancreatic perivascular epithelioid cell tumors: A case series
Sign Up to like & getrecommendations! Published in 2019 at "Diagnostic Cytopathology"
DOI: 10.1002/dc.24111
Abstract: Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal tumors that can affect any part of the body. They can be sporadic or arise in the setting of tuberous sclerosis (TSC). In this article, we report… read more here.
Keywords: epithelioid; epithelioid cell; perivascular epithelioid; cell tumors ... See more keywords
Can EUS‐FNA cytology reliably classify gastric submucosal spindle cell tumors?
Sign Up to like & getrecommendations! Published in 2023 at "Diagnostic Cytopathology"
DOI: 10.1002/dc.25097
Abstract: Cytological diagnosis using endoscopic ultrasound‐guided fine‐needle aspiration (EUS‐FNA) for gastric submucosal spindle cell tumors, such as gastrointestinal stromal tumors (GISTs), leiomyomas, and schwannomas, is challenging because of their similar morphological characteristics. read more here.
Keywords: gastric submucosal; eus fna; spindle cell; submucosal spindle ... See more keywords
Upper gastrointestinal bleed as the initial presentation of seminoma involving the duodenum in an elderly patient with 9 year follow up: A case report and literature review
Sign Up to like & getrecommendations! Published in 2023 at "Diagnostic Cytopathology"
DOI: 10.1002/dc.25119
Abstract: Germ cell tumors are the most common malignancies in males between 20 and 40 years. However, primary extragonadal germ cell tumors are rare and account for 2%–5% of all germ cell neoplasms in adults. Extragonadal germ… read more here.
Keywords: germ cell; germ; upper gastrointestinal; gastrointestinal bleed ... See more keywords
Frequent mutations of genes encoding vacuolar H+‐ATPase components in granular cell tumors
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DOI: 10.1002/gcc.22727
Abstract: Granular cell tumors (GCTs) are rare mesenchymal tumors that exhibit a characteristic morphology and a finely granular cytoplasm. The genetic alterations responsible for GCT tumorigenesis had been unknown until recently, when loss‐of‐function mutations of ATP6AP1… read more here.
Keywords: atpase components; atpase; genes encoding; granular cell ... See more keywords
Mutations involving TGFB and MAPK may be associated with malignancy in granular cell tumors
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DOI: 10.1002/gcc.23123
Abstract: Granular cell tumors (GrCTs) are mesenchymal neoplasms of presumed schwannian differentiation that may present as solitary or multifocal lesions with excision usually being curative. A minority of cases, however, show histological features associated with an… read more here.
Keywords: granular cell; associated malignancy; mutations involving; may associated ... See more keywords
A national analysis of patterns of care and outcomes for adults diagnosed with desmoplastic small round cell tumors in the United States
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DOI: 10.1002/jso.25426
Abstract: Because of the rarity of desmoplastic small round cell tumors (DSRCT), there is a lack of data describing patterns of care and survival for these patients. Using a national tumor registry, the current study sought… read more here.
Keywords: round cell; small round; patterns care; desmoplastic small ... See more keywords