A Combinatorial Library of Lipid Nanoparticles for Cell Type-Specific mRNA Delivery.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202301929
Abstract: Ionizable lipid-based nanoparticles (LNPs) are the most advanced non-viral drug delivery systems for RNA therapeutics and vaccines. However, cell type-specific, extrahepatic mRNA delivery is still a major hurdle, hampering the development of novel therapeutic modalities.… read more here.
Keywords: type specific; delivery; mrna delivery; cell type ... See more keywords
Human Brain Cell‐Type‐Specific Aging Clocks Based on Single‐Nuclei Transcriptomics
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202506109
Abstract: Aging is the primary risk factor for most neurodegenerative diseases, yet the cell-type-specific progression of brain aging remains poorly understood. Here, we developed human cell-type-specific transcriptomic aging clocks using high-quality single-nucleus RNA sequencing data from… read more here.
Keywords: type specific; aging clocks; brain; cell ... See more keywords
Metabolic Chemical Reporters of Glycans Exhibit Cell‐Type‐Selective Metabolism and Glycoprotein Labeling
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700020
Abstract: Since the pioneering work by Reutter and co‐workers that demonstrated structural flexibility in the carbohydrate biosynthesis and glycosylation pathways, many different labs have used unnatural monosaccharide analogues to perform glycan engineering on the surface of… read more here.
Keywords: chemical reporters; cell type; reporters glycans; metabolic chemical ... See more keywords
A Cell Type-Specific Role for Tubb6 in Ciliogenesis of Xenopus Epidermal Multiciliated Cells.
Sign Up to like & getrecommendations! Published in 2025 at "Cytoskeleton"
DOI: 10.1002/cm.70056
Abstract: Cilia are microtubule-based organelles found on the surface of most eukaryotic cells. These microtubules are composed of α- and β-tubulin heterodimers, and different tubulin isotypes can confer distinct properties to microtubules. Despite their importance, the… read more here.
Keywords: cilia; xenopus epidermal; multiciliated cells; epidermal multiciliated ... See more keywords
Cell type specific impact of cannabinoid receptor signaling in somatosensory barrel map formation in mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24733
Abstract: Endocannabinoids and their receptors are highly abundant in the developing cerebral cortex and play major roles in early developmental processes, for example, neuronal proliferation, migration, and axonal guidance as well as postnatal plasticity. To investigate… read more here.
Keywords: type specific; barrel; map; cb1 ... See more keywords
Universal cell type identifier based on number theory
Sign Up to like & getrecommendations! Published in 2018 at "Cytometry Part A"
DOI: 10.1002/cyto.a.23346
Abstract: Cell type classification and handling is a key issue for understanding biological systems. The advent of high multiplexing technologies increased the complexity of the classification process and new tools are needed to support the organization… read more here.
Keywords: type identifier; identifier based; universal cell; cell ... See more keywords
Cell type‐dependent functions of microRNA‐92a
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26765
Abstract: The role of miR‐17/92 family in development and progression of various cancers has been established. The members of this miRNA family have been shown to be over expressed and target various genes within proliferation, metastasis… read more here.
Keywords: family; type dependent; cell; cell type ... See more keywords
Human neural cell type‐specific extracellular vesicle proteome defines disease‐related molecules associated with activated astrocytes in Alzheimer's disease brain
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12183
Abstract: Abstract In neurodegenerative diseases, extracellular vesicles (EVs) transfer pathogenic molecules and are consequently involved in disease progression. We have investigated the proteomic profiles of EVs that were isolated from four different human‐induced pluripotent stem cell‐derived… read more here.
Keywords: disease; type specific; brain; cell type ... See more keywords
Benchmarking transcriptome deconvolution methods for estimating tissue‐ and cell‐type‐specific extracellular vesicle abundances
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12511
Abstract: Abstract Extracellular vesicles (EVs) contain cell‐derived lipids, proteins and RNAs; however, determining the tissue‐ and cell‐type‐specific EV abundances in body fluids remains a significant hurdle for our understanding of EV biology. While tissue‐ and cell‐type‐specific… read more here.
Keywords: type specific; cell; tissue cell; deconvolution ... See more keywords
Evolution of homology: From archetype towards a holistic concept of cell type
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Morphology"
DOI: 10.1002/jmor.21569
Abstract: The concept of homology lies in the heart of comparative biological science. The distinction between homology as structure and analogy as function has shaped the evolutionary paradigm for a century and formed the axis of… read more here.
Keywords: cell; cell types; evolution; concept ... See more keywords
Comparative Structural and Mechanical Characterization of FDM 3D‐Printed PLA Scaffolds for Bone Tissue Engineering Applications
Sign Up to like & getrecommendations! Published in 2025 at "Polymers for Advanced Technologies"
DOI: 10.1002/pat.70257
Abstract: Cellular scaffolds can provide morphological and mechanical integrity with human bone. Various structural designs have been studied; however, their structural and mechanical properties have not been sufficiently compared under the same conditions. This study investigates… read more here.
Keywords: unit; structural mechanical; unit cell; size ... See more keywords