Leukemic stem cells activate lineage inappropriate signalling pathways to promote their growth
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DOI: 10.1038/s41467-024-45691-4
Abstract: Acute Myeloid Leukemia (AML) is caused by multiple mutations which dysregulate growth and differentiation of myeloid cells. Cells adopt different gene regulatory networks specific to individual mutations, maintaining a rapidly proliferating blast cell population with… read more here.
Keywords: signalling pathways; stem cells; cells activate; leukemic stem ... See more keywords