Cell Aggregation Culture Induces Functional Differentiation of Induced Hepatocyte-like Cells through Activation of Hippo Signaling.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.09.010
Abstract: Recent progress in direct lineage reprogramming has enabled the generation of induced hepatocyte-like (iHep) cells and revealed their potential as an alternative to hepatocytes for medical applications. However, the hepatic functions of iHep cells are… read more here.
Keywords: induced hepatocyte; hepatocyte like; cells activation; ihep ... See more keywords
Physical exercise contributes to cisplatin‐induced nephrotoxicity protection with decreased CD4+ T cells activation
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2018.08.014
Abstract: HighlightsCisplatin decreases spleen weight, but increases T CD4+ cells activation.Exercise restrains T CD4+ cells activation in kidney lymph nodes in cisplatin AKI.Exercise diminishes T cells cytokines production protecting from AKI. &NA; Cisplatin is a chemotherapy… read more here.
Keywords: cd4 cells; cells activation; cisplatin; exercise ... See more keywords
Application of advanced microscopic methods to study the interaction of carboxylated fluorescent nanodiamonds with membrane structures in THP-1 cells: Activation of inflammasome NLRP3 as the result of lysosome destabilisation.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.9b00225
Abstract: Nanodiamonds (ND), especially fluorescent nanodiamonds represent potentially applicable drugs and probes carriers for in vitro/in vivo applications. The main purpose of this study was to relate physical-chemical properties of carboxylated ND to their intracellular distribution,… read more here.
Keywords: microscopic methods; cells activation; fluorescent nanodiamonds; inflammasome nlrp3 ... See more keywords
H3K9 dimethylation safeguards cancer cells against activation of the interferon pathway
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DOI: 10.1126/sciadv.abf8627
Abstract: Activation of interferon genes constitutes an important anticancer pathway able to restrict proliferation of cancer cells. Here, we demonstrate that the H3K9me3 histone methyltransferase (HMT) suppressor of variegation 3–9 homolog 1 (SUV39H1) is required for… read more here.
Keywords: cells activation; activation interferon; interferon pathway; pathway ... See more keywords
Mechanically Optimize T Cells Activation by Spiky Nanomotors
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.844091
Abstract: T cell activation is vital for immune response initiation and modulation. Except for the strength of the interaction between T cell receptors (TCR) and peptides on major histocompatibility complex molecules (MHC), mechanical force, mediated by… read more here.
Keywords: spiky nanomotors; mechanically optimize; optimize cells; cells activation ... See more keywords