Autophagy induction sensitizes cancer cells to anti-cancer drugs.
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2162703
Abstract: Resistance to anti-cancer therapy is a major challenge for cancer treatment. Many studies revealed that macroautophagy/autophagy inhibition can overcome autophagy-mediated therapy resistance, but these efforts have not yet led to the success of clinical applications.… read more here.
Keywords: cancer; anti cancer; cancer drugs; autophagy induction ... See more keywords
Targeting regulatory T cells in anti‐PD‐1/PD‐L1 cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2021 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.13129
Abstract: The programmed death (PD)‐1/PD‐ligand (PD‐L) pathway and regulatory T cells (Tregs) are essential for the maintenance of immune tolerance. Their activation in the tumour microenvironment contributes to the evasion of the transformed cells from the… read more here.
Keywords: cells anti; targeting regulatory; regulatory cells; cancer immunotherapy ... See more keywords
P06.12 Combination therapy of CAR-NK-cells and anti-PD-1 antibody results in high efficacy against advanced-stage glioblastoma in a syngeneic mouse model and induces protective anti-tumor immunity in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-itoc7.91
Abstract: Background Checkpoint inhibitors as well as adoptive cell therapy hold great promise for cancer therapy and encouraging treatment responses have already been demonstrated in different cancer indications. Glioblastoma (GB) is the most common and aggressive… read more here.
Keywords: therapy; none; combination; cells anti ... See more keywords
Imaging of tumor infiltrating T cells with an anti-CD8 minibody (Mb) 89Zr-IAB22M2C, in advanced solid tumors.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e24160
Abstract: e24160Background: The degree of tumor infiltration by CD8 T cells is associated with favorable outcomes to immunotherapy. Biopsies to assess T cell infiltration are invasive and may not capture het... read more here.
Keywords: imaging tumor; cd8; cells anti; tumor infiltrating ... See more keywords
Treating iPSC-Derived β Cells with an Anti-CD30 Antibody–Drug Conjugate Eliminates the Risk of Teratoma Development upon Transplantation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23179699
Abstract: Insulin-producing cells derived from induced pluripotent stem cells (iPSCs) are promising candidates for β cell replacement in type 1 diabetes. However, the risk of teratoma formation due to residual undifferentiated iPSCs contaminating the differentiated cells… read more here.
Keywords: ipsc derived; teratoma; cells anti; anti cd30 ... See more keywords