Differential effects of Wnt-β-catenin signaling in Purkinje cells and Bergmann glia in spinocerebellar ataxia type 1
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DOI: 10.1073/pnas.2208513119
Abstract: Significance The mechanisms underlying the degeneration of specific cellular populations in various neurodegenerative disorders remain unknown. Here, we show that the polyQ expansion of ataxin-1 activates the Wnt-β-catenin signaling pathway in various cell types, including… read more here.
Keywords: bergmann glia; wnt catenin; purkinje cells; catenin signaling ... See more keywords