Harnessing neoantigen specific CD4 T cells for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.5ri0220-603rr
Abstract: The goal of precision immunotherapy is to direct a patient's T cell response against the immunogenic mutations expressed on their tumors. Most immunotherapy approaches to‐date have focused on MHC class I‐restricted peptide epitopes by which… read more here.
Keywords: cd4 cells; immunotherapy; cells cancer; cancer immunotherapy ... See more keywords
Microencapsulated Cells for Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6364-5_21
Abstract: The microencapsulation of different types of cells that are able to produce therapeutic factors is being investigated for the treatment of several human diseases. Most efforts are focused on chronic and degenerative diseases as this… read more here.
Keywords: cells cancer; microencapsulated cells; therapy; oncology ... See more keywords
EV, Microvesicles/MicroRNAs and Stem Cells in Cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-74470-4_8
Abstract: The role of extracellular vesicles (EV) in carcinogenesis has become the focus of much research. These microscopic messengers have been found to regulate immune system function, particularly in tumorigenesis, as well as conditioning future metastatic… read more here.
Keywords: micrornas stem; cells cancer; biology; cancer ... See more keywords
Role of interleukin (IL)-17 and T-helper (Th)17 cells in cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.08.109
Abstract: Interleukin-17 (IL-17), a pleiotropic proinflammatory cytokine, is reported to be significantly generated by a distinct subset of CD4+ T-cells, upgrading cancer-elicited inflammation and preventing cancer cells from immune surveillance. T-helper (Th)17 cells produced from naive CD4+… read more here.
Keywords: interleukin helper; role interleukin; cells cancer; helper cells ... See more keywords
Senescent cells in cancer therapy: why and how to remove them.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.07.002
Abstract: Cellular senescence is a stress response that imposes a growth arrest on cancer and nonmalignant cells during cancer therapy. By secreting a plethora of proinflammatory factors collectively termed the senescence-associated secretory phenotype (SASP), therapy-induced senescent… read more here.
Keywords: therapy; senescent cells; cancer therapy; cells cancer ... See more keywords
Natural Killer Cells in Cancer and Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.07.032
Abstract: The detection and killing of neoplastic cells require coordination of a variety of antitumor effector cells. Natural killer (NK) cells of the innate immune system are at the forefront of the body's defense systems and… read more here.
Keywords: natural killer; cells cancer; cancer cancer; cancer immunotherapy ... See more keywords
B cells and cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer cell"
DOI: 10.1016/j.ccell.2021.09.007
Abstract: Tumor-infiltrating B cells complement T cell-mediated antitumor immunity. A panel of experts share their views on the complexity of B cells within the tumor microenvironment, the variety of mechanisms by which these cells control tumor growth,… read more here.
Keywords: cancer; cells cancer; tumor;
Dendritic cells in cancer: the role revisited.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2017.01.002
Abstract: Dendritic cells (DCs) with their potent antigen presenting ability are long considered as critical factor in antitumor immunity. Despite high potential in promoting antitumor responses, tumor-associated DCs are largely defective in their functional activity and… read more here.
Keywords: cancer role; dcs; cells cancer; dendritic cells ... See more keywords
Harnessing TH9 cells in cancer immunotherapy.
Sign Up to like & getrecommendations! Published in 2021 at "Seminars in immunology"
DOI: 10.1016/j.smim.2021.101477
Abstract: CD4 T cell effector subsets not only profoundly affect cancer progression, but recent evidence also underscores their critical contribution to the anticancer efficacy of immune checkpoint inhibitors. In 2012, the two seminal studies suggested the… read more here.
Keywords: th9 cells; cells cancer; cancer immunotherapy; cancer ... See more keywords
Genetically engineered T cells for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2019 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-019-0070-9
Abstract: T cells in the immune system protect the human body from infection by pathogens and clear mutant cells through specific recognition by T cell receptors (TCRs). Cancer immunotherapy, by relying on this basic recognition method,… read more here.
Keywords: genetically engineered; engineered cells; cancer immunotherapy; cells cancer ... See more keywords
PD-L1 and ICOSL discriminate human Secretory and Helper dendritic cells in cancer, allergy and autoimmunity.
Sign Up to like & getrecommendations! Published in 2022 at "Nature communications"
DOI: 10.1038/s41467-022-29516-w
Abstract: Dendritic cells (DC) are traditionally classified according to their ontogeny and their ability to induce T cell response to antigens, however, the phenotypic and functional state of these cells in cancer does not necessarily align… read more here.
Keywords: cells cancer; dcs; dendritic cells; cancer ... See more keywords