Designer Solid Self-Emulsifying Nanovaccines Enable Dual Modulation of Dendritic Cells and T Cells for Potent Antitumor Immunity.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202512139
Abstract: Peptide-based cancer vaccines offer favorable safety and stability profiles but are limited by rapid clearance and poor immunogenicity. Here, a ≈20 nm solid self-emulsifying (SSE) nanovaccine platform that co-delivers peptide antigens and an oligonucleotide adjuvant containing… read more here.
Keywords: designer solid; cells cells; dendritic cells; solid self ... See more keywords
Dominant immune cells in pregnancy and pregnancy complications: T helper cells (TH1/TH2, TH17/Treg cells), NK cells, MDSCs, and the immune checkpoints
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11955
Abstract: Pregnancy problems including recurrent pregnancy loss, repeated implantation failure and pre‐eclampsia are common problems in the reproductive ages. Different reasons such as genetic, immunological, and environmental agents and also infections could develop these complications. In… read more here.
Keywords: treg cells; immune checkpoints; pregnancy; immune cells ... See more keywords
Basics of Inducible Lymphoid Organs.
Sign Up to like & getrecommendations! Published in 2020 at "Current topics in microbiology and immunology"
DOI: 10.1007/82_2020_218
Abstract: Tertiary lymphoid organs (TLOs), also known as inducible lymphoid organs, tertiary lymphoid structures, tertiary lymphoid tissues, or ectopic lymphoid organs are accumulations of cells in chronic inflammation that have been observed in most tissues in… read more here.
Keywords: lymphoid organs; inducible lymphoid; microbiology; tertiary lymphoid ... See more keywords
Immunopathogenesis of HBV Infection.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-9151-4_4
Abstract: More than 95% of adult infected with HBV show acute self-limited infection and eventually eliminate the virus. In contrast, about 90% of people exposed to HBV in early childhood develop chronic infection. The specificity of… read more here.
Keywords: immune; immunopathogenesis hbv; infection; hbv infection ... See more keywords
Suppressive activity of Vδ2+ γδ T cells on αβ T cells is licensed by TCR signaling and correlates with signal strength
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-019-02469-8
Abstract: Despite recent progress in the understanding of γδ T cells’ roles and functions, their interaction with αβ T cells still remains to be elucidated. In this study, we sought to clarify what precisely endows peripheral… read more here.
Keywords: strength; activity; cells licensed; suppressive activity ... See more keywords
CD8+ T Cells and NK Cells: Parallel and Complementary Soldiers of Immunotherapy.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in chemical engineering"
DOI: 10.1016/j.coche.2017.11.006
Abstract: CD8+ T cells and NK cells are both cytotoxic effector cells of the immune system, but the recognition, specificity, sensitivity, and memory mechanisms are drastically different. While many of these topics have been extensively studied… read more here.
Keywords: parallel complementary; cd8 cells; cells parallel; complementary soldiers ... See more keywords
The interplay between innate lymphoid cells and T cells
Sign Up to like & getrecommendations! Published in 2020 at "Mucosal Immunology"
DOI: 10.1038/s41385-020-0320-8
Abstract: ILCs and T cells are closely related functionally but they significantly differ in their ability to circulate, expand, and renew. Cooperation and reciprocal functional regulation suggest that these cell types are more complementary than simply… read more here.
Keywords: interplay innate; innate lymphoid; lymphoid cells; cell ... See more keywords
The deubiquitinase Otub1 controls the activation of CD8 T cells and NK cells by regulating IL-15-mediated priming
Sign Up to like & getrecommendations! Published in 2019 at "Nature immunology"
DOI: 10.1038/s41590-019-0405-2
Abstract: CD8+ T cells and natural killer (NK) cells are central cellular components of immune responses against pathogens and cancer, which rely on interleukin (IL)-15 for homeostasis. Here we show that IL-15 also mediates homeostatic priming… read more here.
Keywords: cd8; deubiquitinase otub1; cd8 cells; activation ... See more keywords
Single-cell transcriptomics analysis reveals a disrupted NK-T cell interaction network in liver metastatic cancer
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-06241-0
Abstract: Natural killer (NK) cells and T cells play crucial roles in liver metastatic cancer, particularly through their cytotoxic effects on tumor cells. Although existing evidence suggests a functional network of mutual regulation between NK and… read more here.
Keywords: cancer; cells cells; cell; network ... See more keywords
β-Sitosterol inhibits ovalbumin-induced asthma-related inflammation by regulating dendritic cells
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2022.2102990
Abstract: Abstract Aim To investigate the effects of β-sitosterol (B-SIT) and the underlying mechanisms of action in an ovalbumin-induced rat model of asthma. Methods The pathological and morphological changes in lung and tracheal tissues were observed… read more here.
Keywords: sit; ovalbumin induced; regulating dendritic; inflammation regulating ... See more keywords
The number of nuclei in compacted embryos, assessed by optical coherence microscopy, is a non-invasive and robust marker of mouse embryo quality
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Human Reproduction"
DOI: 10.1093/molehr/gaae012
Abstract: Abstract Optical coherence microscopy (OCM) visualizes nuclei in live, unlabeled cells. As most cells are uninucleated, the number of nuclei in embryos may serve as a proxy of the cell number, providing important information on… read more here.
Keywords: number; embryo quality; number nuclei; cells cells ... See more keywords