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   Articles with "cells cisplatin" as a keyword



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Hsp90 inhibition sensitizes DLBCL cells to cisplatin

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recommendations! Published in 2022 at "Cancer Chemotherapy and Pharmacology"

DOI: 10.1007/s00280-022-04407-5

Abstract: Platinum-containing therapy is standard treatment for relapsed Diffuse Large B-Cell Lymphoma (DLBCL). However, the efficacy of treatment is limited by drug resistance leading to relapse. Cisplatin resistance has been linked to impairments of the DNA… read more here.

Keywords: dlbcl cells; hsp90; combination; cells cisplatin ... See more keywords
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Downregulation of topoisomerase 1 and 2 with acriflavine sensitizes bladder cancer cells to cisplatin-based chemotherapy.

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recommendations! Published in 2022 at "Molecular biology reports"

DOI: 10.1007/s11033-021-07087-1

Abstract: BACKGROUND Resistance to cisplatin is a major obstacle to effective treatment of bladder cancer (BC). The present study aimed to determine whether a combination of acriflavine (ACF) with cisplatin could potentiate the antitumor property of… read more here.

Keywords: based chemotherapy; cells cisplatin; cisplatin based; bladder cancer ... See more keywords
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ATM inhibition induces synthetic lethality and enhances sensitivity of PTEN‐deficient breast cancer cells to cisplatin

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recommendations! Published in 2018 at "Experimental Cell Research"

DOI: 10.1016/j.yexcr.2018.03.006

Abstract: ABSTRACT PTEN deficiency often causes defects in DNA damage repair. Currently, effective therapies for breast cancer are lacking. ATM is an attractive target for cancer treatment. Previous studies suggested a synthetic lethality between PTEN and… read more here.

Keywords: cells cisplatin; breast cancer; pten deficient; cancer cells ... See more keywords
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Inhibition of lncRNA NEAT1 sensitizes medulloblastoma cells to cisplatin through modulating the miR-23a-3p-glutaminase (GLS) axis.

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recommendations! Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2021.2008695

Abstract: Medulloblastoma (MB) is a commonly occurring brain malignancy in adolescence. Currently, the combination of chemotherapy with subsequent irradiation is a regular therapeutic strategy. However, high dosage of chemotherapy is associated with drug resistance and side… read more here.

Keywords: mir 23a; cells cisplatin; resistant cells; cisplatin resistant ... See more keywords
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FOXO1 and FOXO3a sensitize non-small-cell lung cancer cells to cisplatin-induced apoptosis independent of Bim.

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recommendations! Published in 2020 at "Acta biochimica et biophysica Sinica"

DOI: 10.1093/abbs/gmaa129

Abstract: Low sensitivity to chemotherapy has been a major challenge in the treatment of non-small-cell lung cancer (NSCLC). It is of great clinical significance to discover its mechanisms to improve cell sensitivity to chemotherapeutic drugs. The… read more here.

Keywords: cells cisplatin; foxo3a; non small; cell ... See more keywords
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Inhibition of STX17-SNAP29-VAMP8 complex formation by costunolide sensitizes ovarian cancer cells to cisplatin via the AMPK/mTOR signaling pathway.

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recommendations! Published in 2023 at "Biochemical pharmacology"

DOI: 10.2139/ssrn.4355126

Abstract: Ovarian cancer (OC) is the most common gynecological malignancy. Chemotherapy failure is a major challenge in OC treatment. Targeting autophagy is a promising strategy to enhance the cytotoxicity of chemotherapeutic agents. In this study, we… read more here.

Keywords: stx17 snap29; ovarian cancer; ampk mtor; cells cisplatin ... See more keywords
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miR‑501‑3p sensitizes glioma cells to cisplatin by targeting MYCN.

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recommendations! Published in 2018 at "Molecular medicine reports"

DOI: 10.3892/mmr.2018.9458

Abstract: Cisplatin, a commonly used chemotherapeutic agent for glioma patients, treatment often leads to chemoresistance. Accumulating evidence has demosntrated that microRNA (miRNA/miR) is involved in drug resistance of glioma cells. Nevertheless, the role of miR‑501‑3p in… read more here.

Keywords: mir 501; cells cisplatin; glioma cells; glioma ... See more keywords
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The Hu antigen R/interferon-β axis modulates sensitivity of esophageal squamous cancer cells to cisplatin.

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recommendations! Published in 2022 at "Neoplasma"

DOI: 10.4149/neo_2022_210910n1299

Abstract: The incidence rate of esophageal squamous cell carcinoma (ESCC) has risen significantly in recent years. RNA binding protein (RBP) has been attracting increased attention in the treatment of ESCC. Therefore, the primary aim of this… read more here.

Keywords: hur; cell; escc; cells cisplatin ... See more keywords
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Downregulation of FoxM1 sensitizes nasopharyngeal carcinoma cells to cisplatin via inhibition of MRN-ATM-mediated DNA repair

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recommendations! Published in 2019 at "BMB Reports"

DOI: 10.5483/bmbrep.2019.52.3.249

Abstract: Chemoresistance is the primary obstacle in the treatment of locally advanced and metastatic nasopharyngeal carcinoma (NPC). Recent evidence suggests that the transcription factor forkhead box M1 (FoxM1) is involved in chemoresistance. Our group previously confirmed… read more here.

Keywords: inhibition mrn; foxm1; cells cisplatin; downregulation foxm1 ... See more keywords