Viral Vectors, Engineered Cells and the CRISPR Revolution.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-63904-8_1
Abstract: Over the past few decades the ability to edit human cells has revolutionized modern biology and medicine. With advances in genome editing methodologies, gene delivery and cell-based therapeutics targeted at treatment of genetic disease have… read more here.
Keywords: medicine; viral vectors; cells crispr; biology ... See more keywords
CRISPR-Cas systems for genome editing of mammalian cells.
Sign Up to like & getrecommendations! Published in 2021 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2021.01.011
Abstract: In the past decade, ZFNs and TALENs have been used for targeted genome engineering and have gained scientific attention. It has demonstrated huge potential for gene knockout, knock-in, and indels in desired locations of genomes… read more here.
Keywords: mammalian cells; genome editing; crispr cas; crispr cas9 ... See more keywords
Applying stem cells and CRISPR engineering to uncover the etiology of schizophrenia
Sign Up to like & getrecommendations! Published in 2021 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2021.04.003
Abstract: Schizophrenia is a highly heritable, polygenic disorder. A growing list of common genetic variants have been associated with schizophrenia; there is a clear need to understand the role of these risk factors in the etiology… read more here.
Keywords: schizophrenia; etiology; cells crispr; crispr engineering ... See more keywords
Generation of genetically tailored porcine liver cancer cells by CRISPR/Cas9 editing.
Sign Up to like & getrecommendations! Published in 2020 at "BioTechniques"
DOI: 10.2144/btn-2020-0119
Abstract: Pigs provide a valuable large animal model for several diseases due to their similarity with humans in anatomy, physiology, genetics and drug metabolism. We recently generated a porcine model for TP53R167H and KRASG12D driven hepatocellular… read more here.
Keywords: crispr cas9; cells crispr; tailored porcine; cas9 editing ... See more keywords