T cells engineered to home in on brain cancer
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/d41586-018-05883-7
Abstract: Immunotherapies activate T cells to destroy tumours, but the approach has failed in some brain cancers. A strategy to improve migration of T cells across the blood–brain barrier could overcome this limitation.A synthetic ligand enhances… read more here.
Keywords: brain cancer; cells engineered; engineered home; home brain ... See more keywords
T cells engineered to target senescence
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/d41586-020-01759-x
Abstract: Senescence is a hallmark of cellular ageing and contributes to many diseases. A new method enabling immune cells to target senescent cells might offer improved therapeutic options. CAR T cells that target senescent cells combat… read more here.
Keywords: target senescence; cells engineered; senescence; engineered target ... See more keywords
CAR T Cells Engineered to Secrete IFNκ Induce Tumor Ferroptosis via an IFNAR/STAT1/ACSL4 Axis
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-24-0130
Abstract: The mechanisms by which IFNκ mediates its functions are unclear. The authors find that IFNκ can enhance tumor cell sensitivity to ferroptosis and that CAR T cells engineered to express IFNκ have enhanced antitumor function… read more here.
Keywords: ferroptosis; tumor; cells engineered; car cells ... See more keywords
GMP-Grade Manufacturing of T Cells Engineered to Express a Defined γδTCR
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01062
Abstract: γ9δ2T cells play a critical role in daily cancer immune surveillance by sensing cancer-mediated metabolic changes. However, a major limitation of the therapeutic application of γ9δ2T cells is their diversity and regulation through innate co-receptors.… read more here.
Keywords: cells engineered; express defined; gmp grade; engineered express ... See more keywords