Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer cell"
DOI: 10.1016/j.ccell.2021.02.016
Abstract: Many cancers, including pancreatic ductal adenocarcinoma (PDAC), depend on autophagy-mediated scavenging and recycling of intracellular macromolecules, suggesting that autophagy blockade should cause tumor starvation and regression. However, until now autophagy-inhibiting monotherapies have not demonstrated potent… read more here.
Keywords: macropinocytosis; cells escape; inhibition; autophagy ... See more keywords
Stem cells: Escape from the Jedi
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Immunology"
DOI: 10.1038/nri.2018.18
Abstract: Quiescent adult stem cells escape immune surveillance by downregulating the antigen presentation machinery. read more here.
Keywords: cells escape; stem cells; escape jedi;
Cardiac interstitial tetraploid cells can escape replicative senescence in rodents but not large mammals
Sign Up to like & getrecommendations! Published in 2019 at "Communications Biology"
DOI: 10.1038/s42003-019-0453-z
Abstract: Cardiomyocyte ploidy has been described but remains obscure in cardiac interstitial cells. Ploidy of c-kit+ cardiac interstitial cells was assessed using confocal, karyotypic, and flow cytometric technique. Notable differences were found between rodent (rat, mouse)… read more here.
Keywords: escape replicative; interstitial cells; cardiac interstitial; cells escape ... See more keywords