Targeted editing of the PSIP1 gene encoding LEDGF/p75 protects cells against HIV infection
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-38718-0
Abstract: To fulfill a productive infection cycle the human immunodeficiency virus (HIV) relies on host-cell factors. Interference with these co-factors holds great promise in protecting cells against HIV infection. LEDGF/p75, encoded by the PSIP1 gene, is… read more here.
Keywords: ledgf p75; hiv infection; p75; cells hiv ... See more keywords
Mapping the interplay between NK cells and HIV: therapeutic implications
Sign Up to like & getrecommendations! Published in 2023 at "Journal of leukocyte biology"
DOI: 10.1093/jleuko/qiac007
Abstract: Although highly effective at durably suppressing plasma HIV-1 viremia, combination antiretroviral therapy (ART) treatment regimens do not eradicate the virus, which persists in long-lived CD4+ T cells. This latent viral reservoir serves as a source… read more here.
Keywords: cell; hiv; mapping interplay; interplay cells ... See more keywords
HIV fragments detected in Kaposi sarcoma tumor cells in HIV-infected patients
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000031310
Abstract: Kaposi sarcoma (KS) is a malignant vascular neoplasm caused by KS-associated herpesvirus (KSHV) infection. HIV plays a major role in KS pathogenesis. KS in HIV usually produces more malignant features than classic KS. Despite the… read more here.
Keywords: hiv; tumor cells; kshv; kaposi sarcoma ... See more keywords
HIV-1 Infection of Renal Cells in HIV-Associated Nephropathy.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2016111171
Abstract: “If there is one thing the history of evolution has taught us it’s that life will not be contained. Life breaks free, it expands to new territories and crashes through barriers.” (Dr. Ian Malcolm in… read more here.
Keywords: associated nephropathy; hiv infection; cells hiv; infection renal ... See more keywords
Targeting NK Cells for HIV-1 Treatment and Reservoir Clearance
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.842746
Abstract: Combined antiretroviral therapy (cART) can inhibit the replication of human immunodeficiency virus type 1 (HIV-1) and reduce viral loads in the peripheral blood to undetectable levels. However, the presence of latent HIV-1 reservoirs prevents complete… read more here.
Keywords: reservoir clearance; reservoir; targeting cells; cells hiv ... See more keywords
CD38+CD39+ NK cells associate with HIV disease progression and negatively regulate T cell proliferation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.946871
Abstract: The ectonucleotidases CD38 and CD39 have a critical regulatory effect on tumors and viral infections via the adenosine axis. Natural killer (NK) cells produce cytokines, induce cytotoxic responses against viral infection, and acquire immunoregulatory properties.… read more here.
Keywords: cell; proliferation; cd39 cells; cells hiv ... See more keywords