A Glucose-Triptolide Conjugate Selectively Targets Cancer Cells under Hypoxia
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101536
Abstract: Summary A major hurdle in the treatment of cancer is chemoresistance induced under hypoxia that is characteristic of tumor microenvironment. Triptolide, a potent inhibitor of eukaryotic transcription, possesses potent antitumor activity. However, its clinical potential… read more here.
Keywords: triptolide conjugate; cells hypoxia; antitumor activity; cancer cells ... See more keywords
Characterization of Chlorogenic Acid as a Two-Photon Fluorogenic Probe that Regulates Glycolysis in Tumor Cells under Hypoxia.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01317
Abstract: High levels of steady-state mitochondrial reactive oxygen species (ROS) and glycolysis are hallmarks of cancer. An improved understanding of interactions between tumor energetics and mitochondrial ROS modulation is useful for the development of new anticancer… read more here.
Keywords: two photon; cells hypoxia; tumor cells; chlorogenic acid ... See more keywords
MAP4 regulates Tctex‐1 and promotes the migration of epidermal cells in hypoxia
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Dermatology"
DOI: 10.1111/exd.13763
Abstract: After acute wound formation, the oxygen supply is reduced, which results in the formation of an acute hypoxic microenvironment; whether this hypoxic microenvironment enhances epidermal cell migration and the underlying regulatory molecular mechanism of this… read more here.
Keywords: map4 regulates; cells hypoxia; cell migration; epidermal cells ... See more keywords
NK Cells Under Hypoxia: The Two Faces of Vascularization in Tumor and Pregnancy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.924775
Abstract: Environmental conditions greatly shape the phenotype and function of immune cells. Specifically, hypoxic conditions that exist within tissues and organs have been reported to affect both the adaptive and the innate immune system. Natural killer… read more here.
Keywords: cells hypoxia; hypoxia two; two faces; immune cells ... See more keywords
Stemness of Human Pluripotent Cells: Hypoxia-Like Response Induced by Low Nitric Oxide
Sign Up to like & getrecommendations! Published in 2021 at "Antioxidants"
DOI: 10.3390/antiox10091408
Abstract: The optimization of conditions to promote the stemness of pluripotent cells in vitro is instrumental for their use in advanced therapies. We show here that exposure of human iPSCs and human ESCs to low concentrations… read more here.
Keywords: pluripotent cells; cells hypoxia; human pluripotent; response ... See more keywords
Effects of miR-210-3p on the erythroid differentiation of K562 cells under hypoxia
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2021.12202
Abstract: GATA binding protein 1 (GATA-1) is one of the most important hematopoietic transcription factors in the production of blood cells, such as platelets, eosinophils, mast cells and erythrocytes. GATA-1 regulates the participation of microRNA (miRNAs/miRs)… read more here.
Keywords: cells hypoxia; k562 cells; erythroid differentiation; differentiation k562 ... See more keywords