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   Articles with "cells imatinib" as a keyword



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Targeted blocking of miR328 lysosomal degradation with alkalized exosomes sensitizes the chronic leukemia cells to imatinib

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recommendations! Published in 2019 at "Applied Microbiology and Biotechnology"

DOI: 10.1007/s00253-019-10127-3

Abstract: Imatinib resistance remains the biggest hurdle for the treatment of chronic myeloid leukemia (CML), with the underlying mechanisms not fully understood. In this study, we found that miR328 significantly and strikingly decreased among other miRNA… read more here.

Keywords: chronic leukemia; leukemia cells; alkalized exosomes; mir328 ... See more keywords
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AICAR and Decitabine Enhance the Sensitivity of K562 Cells to Imatinib by Promoting Mitochondrial Activity

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recommendations! Published in 2020 at "Current Medical Science"

DOI: 10.1007/s11596-020-2266-1

Abstract: Although the advent of tyrosine kinase inhibitors (TKIs) has dramatically improved the survival of patients with chronic myeloid leukaemia (CML), acquired drug resistance and TKI-insensitive leukaemic stem cells (LSCs) remain major obstacles to a CML… read more here.

Keywords: k562 cells; aicar; aicar decitabine; sensitivity k562 ... See more keywords
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Imatinib induces autophagy via upregulating XIAP in GIST882 cells.

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recommendations! Published in 2017 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2017.05.096

Abstract: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms originating from the gastrointestinal tract with gain of function mutations in receptor tyrosine kinases KIT or platelet-derived growth factor receptor A (PDGFRA). The main effective… read more here.

Keywords: imatinib induced; xiap; resistance; gist882 cells ... See more keywords
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Restoration of miR-23a expression by chidamide sensitizes CML cells to imatinib treatment with concomitant downregulation of CRYAB

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recommendations! Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2022.2056322

Abstract: ABSTRACT MicroRNAs (miRNAs) are involved in various processes from the initiation and development of cancers, including chronic myeloid leukemia (CML). In this report, we aimed to investigate the roles of miR-23a in the regulation of… read more here.

Keywords: cml cells; cells imatinib; expression; 23a expression ... See more keywords