PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer cell"
DOI: 10.1016/j.ccell.2021.06.018
Abstract: PARP7 is a monoPARP that catalyzes the transfer of single units of ADP-ribose onto substrates to change their function. Here, we identify PARP7 as a negative regulator of nucleic acid sensing in tumor cells. Inhibition… read more here.
Keywords: type interferon; parp7; cancer; cells inhibition ... See more keywords
Phellodendrine chloride suppresses proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2019.01.060
Abstract: ABSTRACT Despite the massive efforts to develop the treatment of pancreatic cancers, no effective application exhibits satisfactory clinical outcome. Macropinocytosis plays a critical role for continuous proliferation of pancreatic ductal adenocarcinoma (PDAC). In this study,… read more here.
Keywords: macropinocytosis; pancreatic cancer; cancer cells; cells inhibition ... See more keywords