Influence of agomelatine and trastuzumab on the HER2/neu(+), MT1 (+) and MT2 (+) chemo and immunoresistant breast cancer cells lines from the previously treated patients by targeted therapy with trastuzumab.
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DOI: 10.1200/jco.2019.37.15_suppl.e14056
Abstract: e14056 Background: Agomelatine is a melatonin receptor agonist (MT1 and MT2) and a 5-HT2C receptor antagonist. Melatonin is a lipophilic compound that is capable of binding to cell surface receptors, cytosolic sites (calmodulin), and directly… read more here.
Keywords: cells lines; mt1 mt2; trastuzumab; agomelatine trastuzumab ... See more keywords