Contribution of mutant HSC clones to immature and mature cells in MDS and CMML, and variations with AZA therapy.
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DOI: 10.1182/blood.2022018602
Abstract: Myelodysplastic Neoplasms (MDS) and Chronic Myelomonocytic Leukemia (CMML) are clonal disorders driven by progressively acquired somatic mutations in hematopoietic stem cells (HSCs). Hypomethylating agents (HMA) can modify the clinical course of MDS and CMML. Clinical… read more here.
Keywords: immature mature; mature cells; progenitor; mds cmml ... See more keywords