Abstract 3465: HDAC8 regulates immune escape in melanoma through increased transcription of inhibitory cytokines that increase accumulation of myeloid-derived suppressor cells (MDSCs)
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DOI: 10.1158/1538-7445.am2023-3465
Abstract: Immune checkpoint blockade leads to improved and durable responses in 30-40% of melanoma, yet nearly 1/3 of patients relapse from complete remission within 3 years. Recent studies from our group and others demonstrated that upfront… read more here.
Keywords: hdac8; regulates immune; melanoma; immune escape ... See more keywords