The latest role of nerve‐specific splicing factor PTBP1 in the transdifferentiation of glial cells into neurons
Sign Up to like & getrecommendations! Published in 2022 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1740
Abstract: Central nervous system injury diseases can cause the loss of many neurons, and it is difficult to regenerate. The field of regenerative medicine believes that supplementing the missing neurons may be an ideal method for… read more here.
Keywords: cells neurons; latest role; transdifferentiation glial; glial cells ... See more keywords
Geldanamycin-inspired compounds induce direct trans-differentiation of human mesenchymal stem cells to neurons.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.03.082
Abstract: Inspired from geldanamycin, the synthesis of a new series of 20-membered macrocyclic compounds is developed. The key features in our design are (i) retention of the fragment having the precise chiral functional groups of geldanamycin… read more here.
Keywords: human mesenchymal; cells neurons; chemistry; stem cells ... See more keywords
Direct reprogramming of terminally differentiated cells into neurons: A novel and promising strategy for Alzheimer's disease treatment
Sign Up to like & getrecommendations! Published in 2020 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2019.109820
Abstract: Glial activation is a common pathological process of the central nervous system (CNS) in disorders such as Alzheimer's disease (AD). Several approaches have been used to reduce the number of activated astrocytes and microglia in… read more here.
Keywords: alzheimer disease; cells neurons; direct reprogramming; terminally differentiated ... See more keywords
Mechanical role of the submembrane spectrin scaffold in red blood cells and neurons.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cell science"
DOI: 10.1242/jcs.259356
Abstract: Spectrins are large, evolutionarily well-conserved proteins that form highly organized scaffolds on the inner surface of eukaryotic cells. Their organization in different cell types or cellular compartments helps cells withstand mechanical challenges with unique strategies… read more here.
Keywords: red blood; blood cells; cells neurons; role submembrane ... See more keywords