Combining Cell Type-Restricted Adenoviral Targeting with Immunostaining and Flow Cytometry to Identify Cells-of-Origin of Lung Cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7568-6_2
Abstract: Lung cancers display considerable intertumoral heterogeneity, leading to the classification of distinct tumor subtypes. Our understanding of the genetic aberrations that underlie tumor subtypes has been greatly enhanced by recent genomic sequencing studies and state-of-the-art… read more here.
Keywords: lung cancer; cells origin; cell type; type restricted ... See more keywords
Cells of Origin for Prostate Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-32656-2_4
Abstract: Comprehensive knowledge of the normal prostate epithelial lineage hierarchy is a prerequisite to investigate the identity of the cells of origin for prostate cancer. The basal and luminal cells constitute most of the prostate epithelium… read more here.
Keywords: prostate; lineage; prostate cancer; cells origin ... See more keywords
Plasmacytoid dendritic cells: origin matters
Sign Up to like & getrecommendations! Published in 2018 at "Nature Immunology"
DOI: 10.1038/s41590-018-0143-x
Abstract: Plasmacytoid dendritic cells (pDCs) are type I interferon–producing cells with antigen-presenting potential. pDC populations are composed of transcriptionally and functionally heterogeneous cellular subsets with distinct hematopoietic precursor origin. read more here.
Keywords: origin matters; dendritic cells; plasmacytoid dendritic; cells origin ... See more keywords
ATRT-13. DIFFERENT CELLS OF ORIGIN PAVE THE WAY FOR MOLECULAR HETEROGENEITY IN RHABDOID TUMORS
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.012
Abstract: Abstract Rhabdoid tumors (RT) are rare but highly aggressive pediatric neoplasms. These tumors carry homozygous loss-of-function alterations of SMARCB1 in almost all cases with an otherwise low mutational load. RT arise at different intracranial (ATRT)… read more here.
Keywords: rhabdoid tumors; different cells; heterogeneity; atrt ... See more keywords
Extracellular Vesicles Secreted by Mesenchymal Stromal Cells Exert Opposite Effects to Their Cells of Origin in Murine Sodium Dextran Sulfate-Induced Colitis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.627605
Abstract: Several reports have described a beneficial effect of Mesenchymal Stromal Cells (MSCs) and of their secreted extracellular vesicles (EVs) in mice with experimental colitis. However, the effects of the two treatments have not been thoroughly… read more here.
Keywords: extracellular vesicles; mesenchymal stromal; dextran sulfate; stromal cells ... See more keywords
Extracellular vesicles and their cells of origin: Open issues in autoimmune diseases
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1090416
Abstract: The conventional therapeutic approaches to treat autoimmune diseases through suppressing the immune system, such as steroidal and non-steroidal anti-inflammatory drugs, are not adequately practical. Moreover, these regimens are associated with considerable complications. Designing tolerogenic therapeutic… read more here.
Keywords: extracellular vesicles; vesicles cells; autoimmune diseases; origin open ... See more keywords
Neural Stem Cells as Potential Glioblastoma Cells of Origin
Sign Up to like & getrecommendations! Published in 2023 at "Life"
DOI: 10.3390/life13040905
Abstract: Glioblastoma multiforme (GBM) is the most malignant brain tumor in adults and it remains incurable. These tumors are very heterogeneous, resistant to cytotoxic therapies, and they show high rates of invasiveness. Therefore, patients face poor… read more here.
Keywords: glioblastoma; gbm; neural stem; cells origin ... See more keywords