Synthetic peptide-labelled micelles for active targeting of cells overexpressing EGF receptors
Sign Up to like & getrecommendations! Published in 2019 at "Amino Acids"
DOI: 10.1007/s00726-019-02755-w
Abstract: The goal of nanomedicine is to transport drugs to pathological tissues, reducing side effects while increasing targeting and efficacy. Aggregates grafted by bioactive molecules act as the active targeting agents. Among bioactive molecules, peptides, which… read more here.
Keywords: active targeting; peptide; peptide labelled; cells overexpressing ... See more keywords
SHR-A1403, a novel c-Met antibody-drug conjugate, overcomes AZD9291 resistance in NSCLC cells overexpressing c-Met.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer science"
DOI: 10.1111/cas.14180
Abstract: EGFR tyrosine kinase inhibitors (TKIs) have been used as the first-line treatment of non-small cell lung cancers (NSCLCs) harboring EGFR-activating mutations, while acquired resistance is ubiquitous and needs to be solved urgently. Here, we introduce… read more here.
Keywords: resistant cells; cells overexpressing; overexpressing met; resistance ... See more keywords
Abstract B44: Role of EGFR/ERBB4 and MAPK signaling in modulating oncogenic potential of ER+ breast cancer cells overexpressing HER3 mutant
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DOI: 10.1158/1557-3125.advbc17-b44
Abstract: We sought to determine if patient-identified mutations in HER3 enhance ER-mediated transformation in human mammary epithelial cells (MCF-7 and T47D). Furthermore, we examined if HER3 mutations confer resistance to ER-specific inhibitors (fulvestrant and 4-hydroxytamoxifen) in… read more here.
Keywords: overexpressing her3; cells overexpressing; her3 mutant; cancer ... See more keywords
Neuroprotective effects of genistein on SH-SY5Y cells overexpressing A53T mutant α-synuclein
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DOI: 10.4103/1673-5374.235250
Abstract: Genistein, a potent antioxidant compound, protects dopaminergic neurons in a mouse model of Parkinson's disease. However, the mechanism underlying this action remains unknown. This study investigated human SH-SY5Y cells overexpressing the A53T mutant of α-synuclein.… read more here.
Keywords: rotenone; genistein; cells overexpressing; group ... See more keywords