NK cells in pancreatic cancer demonstrate impaired cytotoxicity and a regulatory IL-10 phenotype
Sign Up to like & getrecommendations! Published in 2020 at "Oncoimmunology"
DOI: 10.1080/2162402x.2020.1845424
Abstract: ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is one of the most common tumor subtypes and remains associated with very poor survival. T cell infiltration into tumor tissue is associated with improved clinical outcome but little is… read more here.
Keywords: phenotype; tumor tissue; tumor; cells pancreatic ... See more keywords
Tissue-Resident Memory T Cells in Pancreatic Ductal Adenocarcinoma Coexpress PD-1 and TIGIT and Functional Inhibition Is Reversible by Dual Antibody Blockade
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-22-0121
Abstract: Immunotherapy has had little success in PDAC. The authors report an in-depth investigation of the PDAC tumor microenvironment that highlights PD-1 and TIGIT, or their corresponding ligands, as potential targets for combinatorial therapy to treat… read more here.
Keywords: resident memory; tissue resident; ductal adenocarcinoma; pancreatic ductal ... See more keywords
The Role of Vascular Cells in Pancreatic Beta-Cell Function
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2021.667170
Abstract: Insulin-producing β-cells constitute the majority of the cells in the pancreatic islets. Dysfunction of these cells is a key factor in the loss of glucose regulation that characterizes type 2 diabetes. The regulation of many… read more here.
Keywords: vascular cells; role vascular; pancreatic beta; cells pancreatic ... See more keywords
T cells in pancreatic cancer stroma: Tryptophan metabolism plays an important role in immunoregulation
Sign Up to like & getrecommendations! Published in 2023 at "World Journal of Gastroenterology"
DOI: 10.3748/wjg.v29.i17.2701
Abstract: Several studies have shown that the immune system is highly regulated by tryptophan metabolism, which serves as an immunomodulatory factor. The indoleamine 2,3-dioxygenase 1 (IDO1), as an intracellular enzyme that participates in metabolism of the… read more here.
Keywords: metabolism; tryptophan metabolism; pancreatic cancer; cancer stroma ... See more keywords