USP7 inhibitors, downregulating CCDC6, sensitize lung neuroendocrine cancer cells to PARP-inhibitor drugs.
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DOI: 10.1016/j.lungcan.2016.06.015
Abstract: OBJECTIVES CCDC6 gene product is a tumor-suppressor pro-apoptotic protein, substrate of ATM, involved in DNA damage response and repair. Altered levels of CCDC6 expression are dependent on post-translational modifications, being the de-ubiquitinating enzyme USP7 responsible… read more here.
Keywords: neuroendocrine cancer; cells parp; cancer cells; cancer ... See more keywords