Notch signaling defects in NK cells in patients with cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-020-02763-w
Abstract: Altered expressions of proto-oncogenes have been reported during normal lymphocytes mitogenesis and in T and B lymphocytes in patients with autoimmune diseases. We have recently demonstrated a significantly decreased expression of c-kit and c-Myc in… read more here.
Keywords: patients cancer; cells patients; expression; signaling defects ... See more keywords
Impaired Akt phosphorylation in B-cells of patients with common variable immunodeficiency.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical immunology"
DOI: 10.1016/j.clim.2016.09.009
Abstract: Common variable immunodeficiency (CVID) is a heterogeneous group of primary immunodeficiency characterized by recurrent infections. We evaluated whether defective PI3K/Akt/FoxO pathway could influence B-cell fate. Determination of B-cell subsets in CVD patients and healthy donors… read more here.
Keywords: immunodeficiency; variable immunodeficiency; common variable; cells patients ... See more keywords
Low frequency of IL-10+ B cells in patients with atherosclerosis is related with inflammatory condition
Sign Up to like & getrecommendations! Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2020.e03441
Abstract: Background and aims B cells involvement in animal models of atherosclerosis has been unequivocally established. However, the role of these cells in patients with atherosclerosis is almost unknown. Besides the production of antibodies, B cells… read more here.
Keywords: patients atherosclerosis; frequency; cells patients; frequency cells ... See more keywords
Identification and phenotyping of circulating autoreactive proteinase 3-specific B cells in patients with PR3-ANCA associated vasculitis and healthy controls.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2017.08.006
Abstract: OBJECTIVES To develop a method to detect and phenotype circulating proteinase 3 (PR3)-specific B-cells in patients with PR3-ANCA associated vasculitis (AAV). METHODS Recombinant human PR3 (rPR3) was tagged with FITC or biotin, and its binding… read more here.
Keywords: pr3; patients pr3; pr3 specific; specific cells ... See more keywords
Expansion of circulating extrafollicular helper T-like cells in patients with chronic graft-versus-host disease.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2019.03.006
Abstract: Chronic graft-versus-host disease (cGVHD) is a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Previous studies have shown that T follicular helper cells (Tfh) contribute to immune pathology in cGVHD,… read more here.
Keywords: extrafollicular helper; like cells; cells patients; extrafollicular like ... See more keywords
Increased serum IL-27 concentrations and IL-27-producing cells in MG patients with positive AChR-Ab
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2020.11.017
Abstract: OBJECTIVE This study aims to explore the serum levels of IL-27 and the percentages of IL-27-producing cells in MG patients with positive acetylcholine receptor antibody (AChR-MG). METHODS A total of 17 AChR-MG patients and 22… read more here.
Keywords: patients positive; producing cells; increased serum; cells patients ... See more keywords
Viral infections: Reinvigorating exhausted T cells in hepatitis B infection
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Immunology"
DOI: 10.1038/nri.2017.35
Abstract: hepatitis B virus (HBV), T cells become exhausted, and their antiviral response is weakened. An article in Nature Medicine now shows that reducing mitochondrial dysfunction using mitochondrion-targeted antioxidants in CD8+ T cells from patients with… read more here.
Keywords: chronic hbv; function; infection; cells patients ... See more keywords
Activation or exhaustion of CD8+ T cells in patients with COVID-19
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DOI: 10.1038/s41423-021-00750-4
Abstract: In addition to CD4+ T cells and neutralizing antibodies, CD8+ T cells contribute to protective immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID-19), an ongoing pandemic disease. In patients with COVID-19, CD8+… read more here.
Keywords: cd8; cd8 cells; cells patients; activation exhaustion ... See more keywords
Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19
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DOI: 10.1038/s41591-020-0901-9
Abstract: Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA… read more here.
Keywords: single cell; bronchoalveolar immune; cells patients; bronchoalveolar lavage ... See more keywords
Phenotypic and functional characterization of natural killer cells in rheumatoid arthritis-regulation with interleukin-15
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DOI: 10.1038/s41598-020-62654-z
Abstract: Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation and joint destruction. Previous studies have shown that natural killer (NK) cells may play an important role in the pathogenesis of RA. Interleukin (IL)-15,… read more here.
Keywords: expression cells; natural killer; cells patients; expression ... See more keywords
Increased both PD–L1 and PD–L2 expressions on monocytes of patients with hepatocellular carcinoma was associated with a poor prognosis
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-67497-2
Abstract: Anti-programmed cell death-1 (PD-1) antibodies has been approved to treat HCC. Some PD-1 ligands (PD–L1 and PD–L2) negative tumors respond to treatment of anti-PD-1 antibodies, and this fact may be caused by the expression of… read more here.
Keywords: cells patients; cd14 cells; poor prognosis; associated poor ... See more keywords