T-cells produce acidic niches in lymph nodes to suppress their own effector functions
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17756-7
Abstract: The acidic pH of tumors profoundly inhibits effector functions of activated CD8 + T-cells. We hypothesize that this is a physiological process in immune regulation, and that it occurs within lymph nodes (LNs), which are likely acidic… read more here.
Keywords: lymph nodes; effector functions; acidic niches; activation ... See more keywords
Synthetic cells produce a quorum sensing chemical signal perceived by Pseudomonas aeruginosa.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c7cc09678j
Abstract: Recent developments in bottom-up synthetic biology (e.g., lipid vesicle technology integrated with cell-free protein expression systems) allow the generation of semi-synthetic minimal cells (in short, synthetic cells, SCs) endowed with some distinctive capacities of natural… read more here.
Keywords: natural cells; synthetic cells; pseudomonas aeruginosa; chemical signal ... See more keywords