Germinal Center B Cells Replace Their Antigen Receptors in Dark Zones and Fail Light Zone Entry when Immunoglobulin Gene Mutations are Damaging
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DOI: 10.1016/j.immuni.2018.08.025
Abstract: SUMMARY Adaptive immunity involves the development of bespoke antibodies in germinal centers (GCs) through immunoglobulin somatic hypermutation (SHM) in GC dark zones (DZs) and clonal selection in light zones (LZs). Accurate selection requires that cells… read more here.
Keywords: germinal center; dark zones; center cells; cells replace ... See more keywords