Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14060
Abstract: Somatic mutations in spliceosome genes are detectable in ∼50% of patients with myelodysplastic syndromes (MDS). We hypothesize that cells harbouring spliceosome gene mutations have increased sensitivity to pharmacological perturbation of the spliceosome. We focus on… read more here.
Keywords: u2af1 expressing; mutant u2af1; expressing cells; u2af1 s34f ... See more keywords
MES SV40 Cells Are Sensitive to Lipopolysaccharide, Peptidoglycan, and Poly I:C Expressing IL-36 Cytokines
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DOI: 10.3390/ijms231911922
Abstract: Mesangial cells (MC) maintain the architecture and cellular communication and indirectly join in the glomerular filtration rate for the correct functioning of the glomerulus. Consequently, these cells are activated constantly in response to changes in… read more here.
Keywords: sv40 cells; sensitive lipopolysaccharide; cells sensitive; environment ... See more keywords