Altered X-chromosome inactivation in T cells may promote sex-biased autoimmune diseases.
Sign Up to like & getrecommendations! Published in 2019 at "JCI insight"
DOI: 10.1172/jci.insight.126751
Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disorder that predominantly affects women and is driven by autoreactive T cell-mediated inflammation. It is known that individuals with multiple X-chromosomes are at increased risk for developing SLE;… read more here.
Keywords: xist rna; cells sle; altered chromosome; inactivation cells ... See more keywords
Pathological significance and regulatory mechanism of lymphotoxin β receptor overexpression in T cells of patients with systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biomedical Research"
DOI: 10.7555/jbr.27.20130046
Abstract: Systemic lupus erythematosus (SLE) is a typical autoimmune disease. Lymphotoxin β receptor (LTβR) signaling plays an important role in autoimmune inflammations. LTβR-Ig fusion protein, LTβR blocking agent, has been used to treat SLE, while its… read more here.
Keywords: systemic lupus; cells sle; lymphotoxin receptor; lupus erythematosus ... See more keywords