Endogenous Proteins Modulation in Live Cells with Small Molecules and Light
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200244
Abstract: Protein modulation by light illumination enables the investigation of biological function in high spatiotemporal precision. Compared to genetic methods, the small molecule approach is uniquely suited for modulating endogenous proteins. Endogenous protein modulation in live… read more here.
Keywords: molecules light; endogenous proteins; live cells; small molecules ... See more keywords
The frequency of Th17 cells in the small intestine exhibits a day-night variation dependent on circadian clock activity.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.06.038
Abstract: Interleukin-17-producing CD4+ T helper (Th17) cells are a key immune lineage that protects against bacterial and fungal infections at mucosal surfaces. At steady state, Th17 cells are abundant in the small intestinal mucosa of mice. There… read more here.
Keywords: th17 cells; small intestine; day; th17 ... See more keywords
Human norovirus targets enteroendocrine epithelial cells in the small intestine
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-16491-3
Abstract: Human noroviruses are a major cause of diarrheal illness, but pathogenesis is poorly understood. Here, we investigate the cellular tropism of norovirus in specimens from four immunocompromised patients. Abundant norovirus antigen and RNA are detected… read more here.
Keywords: enteroendocrine epithelial; epithelial cells; targets enteroendocrine; human norovirus ... See more keywords