CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity
Sign Up to like & getrecommendations! Published in 2021 at "Immunity"
DOI: 10.1016/j.immuni.2021.04.009
Abstract: To better understand primary and recall T cell responses during COVID-19, it is important to examine unmanipulated SARS-CoV-2-specific T cells. Using peptide-HLA tetramers for direct ex vivo analysis, we characterized CD8+ T cells specific for… read more here.
Keywords: cells specific; cd8; frequency; cd8 cells ... See more keywords
CD4 T cells specific for factor VIII are present at high frequency in healthy donors and comprise naïve and memory cells.
Sign Up to like & getrecommendations! Published in 2017 at "Blood advances"
DOI: 10.1182/bloodadvances.2017008706
Abstract: We investigated the frequency and subset origin of circulating factor VIII (FVIII)-specific CD4 T cells in healthy donors. Total CD4 T cells and purified CD4 T-cell subsets were stimulated with FVIII-loaded autologous dendritic cells and… read more here.
Keywords: cells specific; cd4 cells; frequency; healthy donors ... See more keywords
Isolation of CD4+ T cells specific for neoantigens created by recurrent driver mutations in non-small cell lung cancer (NSCLC) and melanoma.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.12054
Abstract: 12054Background: T cells specific for neoantigens encoded by mutated genes are increasingly recognized as mediators of tumor destruction after immune checkpoint inhibitor therapy or adoptive cell transfer. Unfortunately, almost all neoantigens result from random mutations… read more here.
Keywords: cells specific; specific neoantigens; recurrent driver; driver mutations ... See more keywords