The loud minority: Transcriptionally active HIV-1-infected cells survive, proliferate, and persist
Sign Up to like & getrecommendations! Published in 2022 at "Cell"
DOI: 10.1016/j.cell.2021.12.038
Abstract: The shock-and-kill strategy reactivates HIV-1 latent reservoir for immune clearance. Einkauf et al. found that some HIV-1-infected cells that persist and proliferate have transcriptionally active HIV-1 in permissive chromatin. Silent proviruses in repressive chromatin resist reactivation.… read more here.
Keywords: hiv infected; transcriptionally active; hiv; cells survive ... See more keywords
Cancer Cells Survive Iron-Poor Cerebrospinal Fluid Using Lipocalin-2.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2020-110
Abstract: The secreted iron-binding protein lipocalin-2 enabled cancer cells to survive in the leptomeninges. read more here.
Keywords: survive iron; cells survive; iron poor; cancer cells ... See more keywords
Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0195956
Abstract: Tenovin-6 is the most studied member of a family of small molecules with antitumour activity in vivo. Previously, it has been determined that part of the effects of tenovin-6 associate with its ability to inhibit… read more here.
Keywords: autophagic flux; blockage; tumour cells; cells survive ... See more keywords