miR-650 promotes motility of anaplastic thyroid cancer cells by targeting PPP2CA
Sign Up to like & getrecommendations! Published in 2019 at "Endocrine"
DOI: 10.1007/s12020-019-01910-3
Abstract: PurposeAberrant expression of miRNAs is crucial in several tissues tumorigenesis including thyroid. Recent studies demonstrated that miR-650 plays different role depending on the cancer type. Herein, we investigated the role of miR-650 in thyroid carcinoma.MethodsThe… read more here.
Keywords: mir 650; ppp2ca; cells targeting; thyroid cancer ... See more keywords
IKZF3 deficiency potentiates chimeric antigen receptor T cells targeting solid tumors.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.10.016
Abstract: Chimeric antigen receptor (CAR) T cell therapy has been successful in treating hematological malignancy, but solid tumors remain refractory. Here, we demonstrated that knocking out transcription factor IKZF3 in HER2-specific CAR T cells targeting breast… read more here.
Keywords: solid tumors; cells targeting; antigen receptor; car ... See more keywords
Extracellular vesicle-mediated delivery of miR-127-3p inhibits the proliferation and invasion of choriocarcinoma cells by targeting ITGA6.
Sign Up to like & getrecommendations! Published in 2022 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2022.113098
Abstract: BACKGROUND Choriocarcinoma (CC) is a highly aggressive malignant tumor that mostly occurs in women of childbearing age. Chemotherapy is the main treatment for CC, but it has side effects and causes drug resistance, which can… read more here.
Keywords: choriocarcinoma; targeting itga6; proliferation invasion; cells targeting ... See more keywords
CAR-T cells targeting a nucleophosmin neoepitope exhibit potent specific activity in mouse models of acute myeloid leukaemia.
Sign Up to like & getrecommendations! Published in 2020 at "Nature biomedical engineering"
DOI: 10.1038/s41551-020-00625-5
Abstract: Therapies employing chimeric antigen receptor T cells (CAR-T cells) targeting tumour-associated antigens (TAAs) can lead to on-target-off-tumour toxicity and to resistance, owing to TAA expression in normal tissues and to TAA expression loss in tumour… read more here.
Keywords: cells targeting; myeloid leukaemia; acute myeloid; car cells ... See more keywords
Development of Engineered CAR T Cells Targeting Tumor-Associated Glycoforms of MUC1 for the Treatment of Intrahepatic Cholangiocarcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Immunotherapy (Hagerstown, Md. : 1997)"
DOI: 10.1097/cji.0000000000000460
Abstract: Intrahepatic cholangiocarcinoma (ICC) is a common malignancy arising from the liver with limited 5-year survival. Thus, there is an urgency to explore new treatment methods. Chimeric antigen receptor T (CAR T) cell therapy is a… read more here.
Keywords: intrahepatic cholangiocarcinoma; cells targeting; car; icc ... See more keywords
Shrimp miR-S8 Suppresses the Stemness of Human Melanoma Stem-like Cells by Targeting the Transcription Factor YB-1.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-17-1375
Abstract: Cross-species regulation of gene expression by microRNA is a possible untapped opportunity for miRNA-based therapy. In this study, we report a novel approach to ablate melanoma stem-like cells by targeting the transcription factor YB-1, which… read more here.
Keywords: stem like; like cells; melanoma stem; cells targeting ... See more keywords
T Cells Targeting MAGE-A4 Shrink Tumors.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-nb2020-059
Abstract: Autologous T cells engineered to target the MAGE-A4 cancer testis antigen successfully shrank a wide range of solid tumors with a manageable toxicity profile. In a phase I trial, the therapy, ADP-A2M4, showed the most… read more here.
Keywords: targeting mage; shrink tumors; mage shrink; mage ... See more keywords
miR-140 Aggravates Chronic Obstructive Pulmonary Disease by Inducing Oxidative Stress in Diaphragm Cells by Targeting Nuclear Factor Erythroid 2-Related Factor 2
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Biomedical Nanotechnology"
DOI: 10.1166/jbn.2023.3497
Abstract: Our research proposes to explore the function of miR-140 in the development of COPD. A COPD model was established in rats, and bronchial epithelial cells (BECs) were extracted in the present study, followed by transfection… read more here.
Keywords: diaphragm cells; mir 140; cells targeting; factor ... See more keywords
Targeting DYRK1B suppresses the proliferation and migration of liposarcoma cells
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DOI: 10.18632/oncotarget.22743
Abstract: Liposarcoma is a common subtype of soft tissue sarcoma and accounts for 20% of all sarcomas. Conventional chemotherapeutic agents have limited efficacy in liposarcoma patients. Expression and activation of serine/threonine-protein kinase dual-specificity tyrosine-(Y)-phosphorylation regulated kinase… read more here.
Keywords: liposarcoma; cells targeting; dyrk1b suppresses; liposarcoma cells ... See more keywords
Apatinib Promotes Ferroptosis in Colorectal Cancer Cells by Targeting ELOVL6/ACSL4 Signaling
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Management and Research"
DOI: 10.2147/cmar.s274631
Abstract: Background Colorectal cancer (CRC) is a common digestive system malignancy. Ferroptosis, a new form of regulated cell death, plays a vital role in the pathogenesis and therapy of cancers. Objective We aimed to study the… read more here.
Keywords: expression; cancer; ferroptosis; colorectal cancer ... See more keywords
miRNA-101-5p inhibits the growth and aggressiveness of NSCLC cells through targeting CXCL6
Sign Up to like & getrecommendations! Published in 2019 at "OncoTargets and therapy"
DOI: 10.2147/ott.s184235
Abstract: Background The purpose of this study is to explore the potential biological roles of miR-101-5p in the progression of non-small-cell lung carcinoma (NSCLC). Methods The levels of miR-101-5p and chemokine (C-X-C motif) ligand 6 (CXCL6)… read more here.
Keywords: growth; mir 101; nsclc cells; targeting cxcl6 ... See more keywords