Glomerular endothelial cells versus podocytes as the cellular target in diabetic nephropathy
Sign Up to like & getrecommendations! Published in 2018 at "Acta Diabetologica"
DOI: 10.1007/s00592-018-1211-2
Abstract: It usually takes several years (in some cases, decades) for predisposed individuals to move from the onset of type 1 or type 2 diabetes to the development of microalbuminuria, the first sign of diabetic nephropathy.… read more here.
Keywords: glomerular endothelial; target; diabetic nephropathy; endothelial cells ... See more keywords
Multiple promoter and enhancer differences likely contribute to augmented G6PC2 expression in human versus mouse pancreatic islet alpha cells.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-24-0051
Abstract: G6PC2 encodes a glucose-6-phosphatase catalytic subunit that opposes the action of glucokinase in pancreatic islets thereby modulating the sensitivity of insulin and glucagon secretion to glucose. In mice, G6pc2 is expressed at ~20-fold higher levels… read more here.
Keywords: cells versus; promoter; g6pc2 expression; expression ... See more keywords