Constrained Nanoparticles Deliver siRNA and sgRNA to T Cells In Vivo without Targeting Ligands.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced materials"
DOI: 10.1002/adma.201902251
Abstract: T cells help regulate immunity, which makes them an important target for RNA therapies. While nanoparticles carrying RNA have been directed to T cells in vivo using protein- and aptamer-based targeting ligands, systemic delivery to… read more here.
Keywords: without targeting; cells vivo; sirna sgrna; deliver sirna ... See more keywords
Generation of Piezo1‐CreER transgenic mice for visualization and lineage tracing of mechanical force responsive cells in vivo
Sign Up to like & getrecommendations! Published in 2022 at "genesis"
DOI: 10.1002/dvg.23476
Abstract: Cells and tissues are exposed to a wide range of mechanical stimuli during development, tissue homeostasis, repair, and regeneration. Over the past few decades, mechanosensitive ion channels (MSCs), as force‐sensing integral membrane proteins, have attracted… read more here.
Keywords: generation piezo1; piezo1; force; cells vivo ... See more keywords
Apoptosis oxidative damage‐mediated and antiproliferative effect of selenylated imidazo[1,2‐a]pyridines on hepatocellular carcinoma HepG2 cells and in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22663
Abstract: Imidazo[1,2‐a]pyridines (IP) and organoselenium compounds have been widely exploited in medicinal chemistry due to their pharmacological activities. Hepatocellular carcinoma (HCC) has few treatment options, and unfortunately, the prognosis is poor. Thus, the development of novel… read more here.
Keywords: hepatocellular carcinoma; cells vivo; apoptosis oxidative; hepg2 cells ... See more keywords
Thymidine Kinase PET Reporter Gene Imaging of Cancer Cells In Vivo.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7860-1_11
Abstract: Positron emission tomography (PET) is a three dimensional imaging modality that detects the accumulation of radiolabeled isotopes in vivo. Ectopic expression of a thymidine kinase reporter gene allows for the specific detection of reporter cells… read more here.
Keywords: reporter; cells vivo; pet; pet reporter ... See more keywords
Targeting infected host cells in vivo via responsive azido-sugar mediated metabolic cell labeling followed by click reaction.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.119843
Abstract: The early in vivo diagnosis of infectious disease foci is largely hindered by invasion and concealment of pathogens in host cells, making it difficult for conventional probes to detect and analyze intracellular pathogens. Taking advantage… read more here.
Keywords: cells vivo; infected host; host cells; targeting infected ... See more keywords
Direct Pharmacological Targeting of a Mitochondrial Ion Channel Selectively Kills Tumor Cells In Vivo.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2017.03.003
Abstract: The potassium channel Kv1.3 is highly expressed in the mitochondria of various cancerous cells. Here we show that direct inhibition of Kv1.3 using two mitochondria-targeted inhibitors alters mitochondrial function and leads to reactive oxygen species… read more here.
Keywords: cells vivo; tumor cells; pharmacological targeting; targeting mitochondrial ... See more keywords
Quinacridone derivative as a new photosensitizer: Photodynamic effects in cells and in vivo
Sign Up to like & getrecommendations! Published in 2017 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2017.06.003
Abstract: Abstract The lack of ideal photosensitizers is the major limitation for clinical photodynamic therapy (PDT). Quinacridone (QA) is a mass-produced industrial organic pigment. QA derivatives are widely investigated for many applications in various fields, but… read more here.
Keywords: cells vivo; new photosensitizer; quinacridone derivative; photosensitizer photodynamic ... See more keywords
PAHs increase the production of extracellular vesicles both in vitro in endothelial cells and in vivo in urines from rats.
Sign Up to like & getrecommendations! Published in 2019 at "Environmental pollution"
DOI: 10.1016/j.envpol.2019.113171
Abstract: Environmental contaminants, to which humans are widely exposed, cause or worsen several diseases, like cardiovascular diseases and cancers. Among these molecules, polycyclic aromatic hydrocarbons (PAHs) stand out since they are ubiquitous pollutants found in ambient… read more here.
Keywords: extracellular vesicles; cells vivo; production; exposure ... See more keywords
AAV6 as an effective gene delivery vector for prolonged transgene expression in intervertebral disc cells in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Genes and Diseases"
DOI: 10.1016/j.gendis.2020.12.009
Abstract: Abstract Intervertebral disc degeneration is the main contributor to low back pain, now the leading cause of disability worldwide. Gene transfer, either in a therapeutic attempt or in basic research to understand the mechanisms of… read more here.
Keywords: cells vivo; transgene expression; delivery; intervertebral disc ... See more keywords
Construction of a TICT-AIE-Integrated Unimolecular Platform for Imaging Lipid Droplet-Mitochondrion Interactions in Live Cells and In Vivo.
Sign Up to like & getrecommendations! Published in 2022 at "ACS sensors"
DOI: 10.1021/acssensors.2c01361
Abstract: Inter-organelle interactions play a vital role in diverse biological processes. Thus, chemical tools are highly desirable for understanding the spatiotemporal dynamic interplay among organelles in live cells and in vivo. However, designing such tools is… read more here.
Keywords: mitochondrion; tict aie; live cells; mitochondrion interactions ... See more keywords
Optimized retroviral transduction of mouse T cells for in vivo assessment of gene function
Sign Up to like & getrecommendations! Published in 2017 at "Nature Protocols"
DOI: 10.1038/nprot.2017.083
Abstract: Retroviral (RV) expression of genes of interest (GOIs) is an invaluable tool and has formed the foundation of cellular engineering for adoptive cell therapy in cancer and other diseases. However, monitoring of transduced T cells… read more here.
Keywords: cells vivo; long term; cd8 cells; transduced cells ... See more keywords