Integrating intracellular and extracellular proteomic profiling for in-depth investigations of cellular communication in a model of prostate cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Proteomics"
DOI: 10.1002/pmic.202200287
Abstract: Cellular communication is essential for cell-cell interactions, maintaining homeostasis and progression of certain disease states. While many studies examine extracellular proteins, the holistic extracellular proteome is often left uncaptured, leaving gaps in our understanding of… read more here.
Keywords: cellular communication; prostate cancer; biology; communication ... See more keywords
Computational exploration of cellular communication in skin from emerging single-cell and spatial transcriptomic data
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society Transactions"
DOI: 10.1042/bst20210863
Abstract: Tissue development and homeostasis require coordinated cell–cell communication. Recent advances in single-cell sequencing technologies have emerged as a revolutionary method to reveal cellular heterogeneity with unprecedented resolution. This offers a great opportunity to explore cell–cell… read more here.
Keywords: cell; communication; cell communication; single cell ... See more keywords
Identify, quantify and characterize cellular communication from single-cell RNA sequencing data with scSeqComm
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac036
Abstract: MOTIVATION Recently, single cell RNA-seq (scRNA-seq) data have been used to study cellular communication. Most bioinformatics methods infer only the intercellular signaling between groups of cells, mainly exploiting ligand-receptor expression levels. Only few methods consider… read more here.
Keywords: communication; identify quantify; single cell; cell rna ... See more keywords
Clinical uses of cellular communication
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.367.6478.637-k
Abstract: Medicine Exosomes are a type of extracellular vesicle that contain constituents (protein, DNA, and RNA) of the cells that secrete them. They are taken up by distant cells, where they can affect cell function and… read more here.
Keywords: medicine; cellular communication; uses cellular; communication ... See more keywords
CCN2 (Cellular Communication Network Factor 2) Deletion Alters Vascular Integrity and Function Predisposing to Aneurysm Formation
Sign Up to like & getrecommendations! Published in 2022 at "Hypertension"
DOI: 10.1161/hypertensionaha.121.18201
Abstract: Supplemental Digital Content is available in the text. Background: CCN2 (cellular communication network factor 2) is a matricellular protein involved in cell communication and microenvironmental signaling responses. CCN2 is known to be overexpressed in several… read more here.
Keywords: ccn2; communication network; network factor; communication ... See more keywords
The Endothelium as a Hub for Cellular Communication in Atherogenesis: Is There Directionality to the Message?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.888390
Abstract: Endothelial cells line every blood vessel and thereby serve as an interface between the blood and the vessel wall. They have critical functions for maintaining homeostasis and orchestrating vascular pathogenesis. Atherosclerosis is a chronic disease… read more here.
Keywords: communication; endothelial cells; endothelium hub; atherogenesis ... See more keywords
Fibroblast Growth Factors and Cellular Communication Network Factors: Intimate Interplay by the Founding Members in Cartilage
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158592
Abstract: Fibroblast growth factors (FGFs) constitute a large family of signaling molecules that act in an autocrine/paracrine, endocrine, or intracrine manner, whereas the cellular communication network factors (CCN) family is composed of six members that manipulate… read more here.
Keywords: growth factors; growth; communication network; fibroblast growth ... See more keywords
LDL Promotes Disorders in β-Cell Cholesterol Metabolism, Implications on Insulin Cellular Communication Mediated by EVs
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12080754
Abstract: Dyslipidemia is described as a hallmark of metabolic syndrome, promoting a stage of metabolic inflammation (metainflammation) that could lead to misbalances in energetic metabolism, contributing to insulin resistance, and modifying intracellular cholesterol pathways and the… read more here.
Keywords: metabolism; cholesterol metabolism; cell cholesterol; cholesterol ... See more keywords