Multifaceted targeted protein degradation systems for different cellular compartments
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DOI: 10.1002/bies.202200008
Abstract: Selective protein degradation maintains cellular homeostasis, but this process is disrupted in many diseases. Targeted protein degradation (TPD) approaches, built upon existing cellular mechanisms, are promising methods for therapeutically regulating protein levels. Here, we review… read more here.
Keywords: cellular compartments; targeting chimeras; protein degradation; targeted protein ... See more keywords
Large-Scale Molecular Dynamics Simulations of Cellular Compartments.
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DOI: 10.1007/978-1-0716-1394-8_18
Abstract: Molecular dynamics or MD simulation is gradually maturing into a tool for constructing in vivo models of living cells in atomistic details. The feasibility of such models is bolstered by integrating the simulations with data… read more here.
Keywords: large scale; simulations cellular; molecular dynamics; cellular compartments ... See more keywords
Metabolic and Cellular Compartments of Acetyl-CoA in the Healthy and Diseased Brain
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DOI: 10.3390/ijms231710073
Abstract: The human brain is characterised by the most diverse morphological, metabolic and functional structure among all body tissues. This is due to the existence of diverse neurons secreting various neurotransmitters and mutually modulating their own… read more here.
Keywords: metabolic cellular; acetyl coa; brain; cellular compartments ... See more keywords