From Cellular Diversity to the Roots of Variability
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DOI: 10.1016/j.cell.2018.11.001
Abstract: Single-cell analyses are propelling us ever closer to answering questions that have long-motivated research in cell and developmental biology. What is the range of cellular diversity? What defines a cell type? How do cell types… read more here.
Keywords: diversity; cellular diversity; roots variability; diversity roots ... See more keywords
Cortical cellular diversity and development in schizophrenia
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DOI: 10.1038/s41380-020-0775-8
Abstract: While a definitive understanding of schizophrenia etiology is far from current reality, an increasing body of evidence implicates perturbations in early development that alter the trajectory of brain maturation in this disorder, leading to abnormal… read more here.
Keywords: schizophrenia; cellular diversity; brain; development ... See more keywords
Cardiomyocyte dedifferentiation and remodeling in 3D scaffolds to generate the cellular diversity of engineering cardiac tissues.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials science"
DOI: 10.1039/c9bm01003c
Abstract: The use of engineered cardiac tissues (ECTs) is a new strategy for the repair and replacement of cardiac tissues in patients with myocardial infarction, particularly at late stages. However, the mechanisms underlying the development of… read more here.
Keywords: cardiac tissues; scaffold microenvironment; cellular diversity; cardiomyocyte dedifferentiation ... See more keywords
Cell Lineage Tracing and Cellular Diversity in Humans.
Sign Up to like & getrecommendations! Published in 2020 at "Annual review of genomics and human genetics"
DOI: 10.1146/annurev-genom-083118-015241
Abstract: Tracing cell lineages is fundamental for understanding the rules governing development in multicellular organisms and delineating complex biological processes involving the differentiation of multiple cell types with distinct lineage hierarchies. In humans, experimental lineage tracing… read more here.
Keywords: lineage; cell lineage; cellular diversity; genetics ... See more keywords
Transcriptional and Cellular Diversity of the Human Heart
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DOI: 10.1161/circulationaha.119.045401
Abstract: Supplemental Digital Content is available in the text. Background: The human heart requires a complex ensemble of specialized cell types to perform its essential function. A greater knowledge of the intricate cellular milieu of the… read more here.
Keywords: human heart; cellular diversity; heart; transcriptional cellular ... See more keywords