Cellular Dynamics Driving Elongation of the Gut.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental cell"
DOI: 10.1016/j.devcel.2018.06.027
Abstract: During embryonic development, the midgut needs to undergo extensive elongation to form the small intestine. In this issue of Development Cell, Wang et. al. (2018) explore the cell dynamics of this tissue and find that… read more here.
Keywords: driving elongation; dynamics driving; elongation; cell ... See more keywords
Short-term dietary restriction maintains synaptic plasticity whereas short-term overfeeding alters cellular dynamics in the aged brain: evidence from the zebrafish model organism
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2021.06.010
Abstract: Increased caloric intake (OF) impairs quality of life causing comorbidities with other diseases and cognitive deficits, whereas dietary restriction (DR) increases healthspan by preventing age-related deteriorations. To understand the effects of these opposing dietary regimens… read more here.
Keywords: term; zebrafish model; dietary restriction; short term ... See more keywords
A deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases.
Sign Up to like & getrecommendations! Published in 2025 at "Nature biomedical engineering"
DOI: 10.1038/s41551-025-01423-7
Abstract: Human diseases are characterized by intricate cellular dynamics. Single-cell transcriptomics provides critical insights, yet a persistent gap remains in computational tools for detailed disease progression analysis and targeted in silico drug interventions. Here we introduce… read more here.
Keywords: disease; silico drug; drug; cell ... See more keywords
Molecular and cellular dynamics of the developing human neocortex
Sign Up to like & getrecommendations! Published in 2025 at "Nature"
DOI: 10.1038/s41586-024-08351-7
Abstract: The development of the human neocortex is highly dynamic, involving complex cellular trajectories controlled by gene regulation1. Here we collected paired single-nucleus chromatin accessibility and transcriptome data from 38 human neocortical samples encompassing both the… read more here.
Keywords: molecular cellular; human neocortex; progenitor; developing human ... See more keywords
Peripheral blood cellular dynamics during the progression of human tuberculosis
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-21181-5
Abstract: Tuberculosis (TB) remains a major global health challenge. Peripheral blood immune cell composition provides valuable insights into TB progression and management. In this study, we analyzed cellular dynamics across the TB disease spectrum using 43… read more here.
Keywords: peripheral blood; progression; tuberculosis; cellular dynamics ... See more keywords
A physics-informed neural SDE network for learning cellular dynamics from time-series scRNA-seq data
Sign Up to like & getrecommendations! Published in 2024 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btae400
Abstract: Abstract Motivation: Learning cellular dynamics through reconstruction of the underlying cellular potential energy landscape (aka Waddington landscape) from time-series single-cell RNA sequencing (scRNA-seq) data is a current challenge. Prevailing data-driven computational methods can be hampered… read more here.
Keywords: sde; potential energy; cellular dynamics; scrna seq ... See more keywords
Phenotypically plastic drug‐resistant chronic myeloid leukaemia cell line displays enhanced cellular dynamics in a zebrafish xenograft model
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.70105
Abstract: Understanding the mechanisms by which cancer cells switch between different adaptive states and evade therapeutic interventions is essential for clinical management. In this study, the in vivo cellular dynamics of a new chronic myeloid leukaemia… read more here.
Keywords: myeloid leukaemia; cell line; cell; cellular dynamics ... See more keywords
Cellular dynamics of distinct skeletal cells and the development of osteosarcoma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1181204
Abstract: Bone contributes to the maintenance of vital biological activities. At the cellular level, multiple types of skeletal cells, including skeletal stem and progenitor cells (SSPCs), osteoblasts, chondrocytes, marrow stromal cells, and adipocytes, orchestrate skeletal events… read more here.
Keywords: skeletal cells; development; bone; skeletal stem ... See more keywords
Effects of Acute Sepsis on Cellular Dynamics and Amyloid Formation in a Mouse Model of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb44090262
Abstract: Our objective was to investigate how sepsis influences cellular dynamics and amyloid formation before and after plaque formation. As such, APP-mice were subjected to a polymicrobial abdominal infection resulting in sepsis at 2 (EarlySepsis) and… read more here.
Keywords: sepsis; amyloid formation; cellular dynamics; formation ... See more keywords