Abstract B068: An in vitro cellular functional STING pathway assay to measure the potency of STING agonists, using interferon-β response
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-17-b068
Abstract: Introduction and Relevance: We have developed an in vitro cellular functional STING pathway assay that can be used to screen for potential therapeutic agents in drug discovery. Stimulator of interferon genes (STING, or TMEM173) is… read more here.
Keywords: cellular functional; interferon; sting agonists; vitro cellular ... See more keywords
Mitochondrial genome variability: the effect on cellular functional activity
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DOI: 10.2147/tcrm.s153895
Abstract: Mitochondria are the key players in cell metabolism, calcium homeostasis, and reactive oxygen species (ROS) production. Mitochondrial genome alterations are reported to be associated with numerous human disorders affecting nearly all tissues. In this review,… read more here.
Keywords: cellular functional; genome variability; effect cellular; mitochondrial genome ... See more keywords
Cellular functional, protective or damaging responses associated with different redox imbalance intensities: a comprehensive review.
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DOI: 10.2174/0929867330666221209093343
Abstract: BACKGROUND Reactive species (RS) are produced in aerobic and anaerobic cells at different concentrations and exposure times, which may trigger diverse responses depending on the cellular antioxidant potential and defensive devices. METHODS Study searches were… read more here.
Keywords: cellular functional; functional protective; protective damaging; redox ... See more keywords